This study presents a structural safety analysis method for a plant annunciator panel under the seismic effect. Seismic qualification analysis for the nuclear plant annunciator panel is carried out to confirm the structural integrity and the results are represented by required response spectra. For the numerical analysis, finite element method is adopted. Mode combinations are also used to obtain the reliability of the spectrum analysis. The analysis results shows that the nuclear plant annunciator panel is designed as a dynamically rigid assembly, without any resonance frequency blow 33Hz. The calculated stress of the nuclear plant annunciator panel is much less than yield stress of used steel.