The natures of fatigue crack growth under Mode Ⅱ loading are studied. End notched flexure beam specimens were used. The effects of adherend thickness, rubber modification and adhesive thickness on fatigue crack growth were examined. The experimental results show that some of these parameters apparently do affect fatigue crack growth. Resistance to ModeⅡ fatigue crack growth are increased by rubber modification. The effects of adhesive thickness and rubber content on fatigue crack growth were explained by von Mises's equivalent stress using BEM analysis. For unmodified epoxy adhesives, the fatigue crack growth properties under Mode Ⅱ loadings were significantly different in all regions. For rubber-modified epoxy adhesives, they were also different in the first and second regions, but in the third region, they were similar