We have performed CFD simulation and analyzed flow and concentration fields for the basic data of the ventilation system for removing pollutants which were produced in a lecture room. The flow patterns indicated differently according to the arrangement of openings and the concentration distribution of pollutants were showed higher and lower because of the effect of that flow patterns. In the case of arranging the openings to the upper and lower side, the stagnation appearance of flow formed in the interested space. In the case of arranging the openings to the right and left side, the stagnation of high concentration pollutants appeared in the middle area of the interested space. On the increasing exhaust velocity, the distribution of pollutants appeared similar to the normal case, but the concentration of pollutants were lower.