구강 선양 낭성 암종에서 예후와 임상병리학적 특성 및 면역조직화학적 발현의 상관성 Relationships Between the Clinicopathologic and Immunohistochemical Profiles and the Prognosis of Oral Adenoid Cystic Carcinomas
pp.203-214
Adenoid cystic carcinoma(ACC) is one of the most common malignant tumors of minor salivary glands and can also arise in a variety of sites in the head and neck including the major salivary glands, the esophagus, the lacrimal glands. ACC shows slow but relentless growth, so it shows long-term recurrence. The various reports about prognostic factors which influence the recurrence pattern are introduced but the reports about prognostic factors are rare in Korean adenoid cystic carcinoma patients. We examined 40 ACC patients who finally diagnosed at Department of Oral Pathology, Seoul National University Dental Hospital. Clinicopathologic and immunohistochemical features were reviewed and factors correlated with recurrence and survival were analyzed. The 5-year survival rate of T3,T4 stage was 31.2%, while that of the T1,T2 stage was 88.2%, and the difference 5-year survival and T stage was statistically significant. The rate of local recurrence was 20% and the rate of distant metastasis was 27.5%. Mean recurrence time were 4.8 years and 5.2 years. There was no significant difference between age, sex, T stage, TNM stage, histologic type and recurrence. But the high T stage and the solid type recurred more frequently. There was no significant difference between recurrence rate, 5-year survival rate and Ki-67, MVD expression. But the higher expression of Ki-67, MVD show the higher recurrence rate and the lower 5-year survival rate
II. 연구재료 및 방법
1) 연구재료
2) 연구방법
3) 염색결과의 판독
4) 통계분석
III. 연구성적
1) 임상병리학적 및 조직학적 소견
2) 종양의 재발
3) 임상병리학적 요소 및 조직학적 형태와 재발율과의 관계
4) 임상병리학적 요소 및 조직학적 형태와 생존율과의 관계
5) 면역조직화학적 소견
6) 면역조직화학적 요소과 재발률, 생존율과의 관계
IV. 고찰
V. 결론
V. 참고문헌