KOREASCHOLAR

Oral squamous cell carcinoma (OSCC) is the most common cancer of oral cancers. Recent data suggest that chemokines could be essential players in carcinogenesis and that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. The aim of this study was to test the hypothesis that expression of SNPs in chemokine, CXCL1 and CXCL2 correlates with oral squamous cell carcinomas in Korean population. The CXCL1 and CXCL2 genotypes were determined in 21 subjects with oral squamous cell carcinoma and 90 control subjects without oral squamous cell carcinoma. The genotypes were determined by direct sequencing. The genotype distribution and allele frequency within the OSCC patients were not significantly different from those of control subjects. But among OSCC subjects, there was significant difference of CXCL1 gene in the degree of nuclear aberration. These findings suggest that CXCL1 -442C/T polymorphism and CXCL2 -264T/C polymorphism are not related to the development of OSCC but polymorphism of CXCL1 gene might have a relation with progression of OSCC in Korean population.

Ⅰ. INTRODUCTION
 Ⅱ. MATERIALS AND METHODS
  1. Study participants
  2. SNP Selection and genotyping
  3. Histological examination
  4. Statistical analysis
 Ⅲ. RESULTS
  1. Clinical and histological characteristics ofpatients with OSCC
  2. Allelic association and CXCL1 and CXCL2haplotypes in patients and controls
  3. Alteration of transcription factor by CXCL1-442C/T and CXCL2 -264T/C single nucleotidepolymorphism
  4. CXCL1 -442C/T and CXCL2 -264T/C singlenucleotide polymorphism in patients andcontrols
  5. CXCL1 -442C/T and CXCL2 -264T/C singlenucleotide polymorphism and nuclearaberration in OSCC patients
 Ⅳ. DISCUSSION
 Ⅴ. REFERENCES

• 강상욱(경희대학교 치의학전문대학원 구강악안면병리학교실) | Sang Wook Kang
• 김준열(경희대학교 치의학전문대학원 구강악안면병리학교실) | Jun Yeul Kim
• 조재오(경희대학교 치의학전문대학원 구강악안) | Jaeo Cho correspondence