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편평상피세포암에서 E-cadherin/beta catenin 발현 및 예후, 전이, 재발에 미치는 영향 Expression of E-cadherin/β-catenin Cell Adhesion Complex in Squamous Cell Carcinoma of Tongue and their Role in Prognosis, Metastasis and Recurrence

KM Ahsan Kabir, 김서연, 임원봉, 김지선, 고영종, 김상우, 오미라, 오희균, 최홍란, 김옥준
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  • URLhttp://db.koreascholar.com/Article/Detail/293217
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대한구강악안면병리학회지
제35권 제6호 (2011.12)
pp.345-358
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Recurrence-metastasis status of squamous cell carcinoma of tongue is a challenging oncologic problem. This study examined the expression of E-cadherin/β-catenin cell adhesion complex in squamous cell carcinoma of the tongue through an immunohistochemical study. Twenty samples from 15 patients with squamous cell carcinoma of the tongue, who were treated at the Department of Oral and Maxillofacial Surgery, consisted of primary or recurrent tumors along with matched metastatic lymph nodes were retrieved for immunohistochemical staining and grouped based on recurrence-metastasis status.Differences in stain localization were noted in E-cadherin, β–catenin and phospho β–catenin staining between different tumor groups based on the recurrence-metastasis status. The number of phospho β-catenin stain positive cells was found to have a significant role in survival. E-cadherin confirms its role as a powerful individual differentiation indicator and the role of β-catenin specially the phospho type elicts interest

키워드
β–catenin phosphoβ–catenin metastasisE-cadherinSquamous ce
목차
Ⅰ. INTRODUCTION
 Ⅱ. MATERIALS AND METHODS
  1. Samples
  2. Data entry
  3. Antibodies and reagents used andtheir specifications
  4. Immunohistochemical procedures
  5. Immunolabelling protocol
  6. Statistical analysis
 Ⅲ. RESULTS
  1. Distribution of cases according to gender and age
  2. Distribution of cases according to the stage ofcancer
  3. Distribution of cases according to the treatment
  4. Expression of E-cadherin, β-catenin andphospho β-catenin in cancer islands
  5. Comparison of stains between different groups
  6. Recurrence and metastasis status andlocalization of stain
  7. Histological differentiation and staining
  8. Survival analysis
 Ⅳ. DISCUSSION
 Ⅴ. REFERENCES
저자
  • KM Ahsan Kabir(Department of Oral Pathology, School of Dentistry, Chonnam National University)
  • 김서연(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Seo Yune Kim
  • 임원봉(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Won Bong Lim
  • 김지선(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Ji Sun Kim
  • 고영종(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Young Jong Ko
  • 김상우(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Sang Woo Kim
  • 오미라(Department of Statistic, Chonnam National University) | Mi Ra Oh
  • 오희균(Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University) | Hee Kyun Oh
  • 최홍란(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Hong Ran Choi
  • 김옥준(Department of Oral Pathology, School of Dentistry, Chonnam National University) | Ok Joon Kim correspondence