A dentigerous cyst (DC) and an odontogenc fibroma (OF) in the jaws are well known entities, which have been reviewed extensively. However, the presence of OF components in the wall of dentigerous cyst is a very rare event. A case of DC in the left mandible displaying the foci of an OF-like lesion is described. It is unclear whether the two lesions were just coincidental or were actually related to each other. However, OF-like proliferation may be arised from secondary epithelial and mesenchymal interactions in a pre-existing DC, although the initiating stimulus could not be identified.