타액선에 발생한 점액표피양암종, 선양낭성암종과 다형성선종간의 Lysyl Oxidase 발현 차이 Differential Expression of Lysyl Oxidase in Mucoepidermoid Carcinoma, Adenoid Cystic Carcinoma and Pleomorphic Adenoma
- 언어KOR
- URLhttp://db.koreascholar.com/Article/Detail/293489
pp.273-280
Lysyl oxidase (LOX) family, the copper dependent amine oxidase, oxidizes lysine residues in extracellular collagen and elastin. LOX increases the strength of the extracellular matrix and plays an important role in tumor development and metastasis. It has been reported that increased LOX protein and RNA are found in head and neck squamous cell carcinoma. Moreover some studies regarded LOX as a prognostic marker of oral and oropharyngeal squamous cell carcinoma. However there has not been any report on LOX expression of salivary gland tumors. Here, we investigated LOX expression in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) of salivary gland and compare it to those of pleomorphic adenoma (PA). We evaluated LOX expression in eighteen MEC, eighteen ACC and twenty PA cases by immunohistochemical examination. Whereas PA showed relatively low density of LOX expression, ACC revealed more cases that showing high staining intensities for LOX. Significantly increased LOX expression was found in the cases of ACC when compared to those of PA (P = 0.010).
Ⅱ. MATERIALS AND METHODS
1. 연구대상
2. 면역조직화학 염색
3. 면역조직화학 염색 결과 평가
4. 통계학적 분석
Ⅲ. RESULTS
1. 성별, 연령 분포 및 발생 부위
2. LOX 면역조직화학 염색 소견
IV. DISCUSSION
V. CONCLUSION
VI. REFERENCES