In this study, it is explored the effect of fashion therapy on depression, positive emotion, negative emotion, appearance interest, body satisfaction, self-esteem, and self-efficacy of female patients. Eight cancer patients and 12 general patients participated in the 4-week fashion therapy program. When comparing results before and after the fashion therapy, depression and negative emotions were significantly decreased while positive emotions and self-efficacy were significantly increased. There was no significant influence on appearance interest, body satisfaction, self-esteem, and self-efficacy. In group comparison, significant changes were observed in depression, positive emotion and negative emotion regardless of groups. However, cancer patients indicated a significant improvement in self-efficacy compared to general patients who did not whereas patients with a high level of depression showed a significant enhancement on body satisfaction compared to patients with a low level of depression. Also, patients with a low level of pain indicated a significant improvement on self-esteem and self-efficacy compared to patients with a high level of pain. Perceived effect and satisfaction of the fashion therapy were relatively high. Study results may positively contribute to building a knowledge and experimental base of fashion therapy that is widely applicable to diverse parties for the future.