KOREASCHOLAR

The Immunoexpression of Visfatin in Oral Carcinogenesis from Korean Patients 한국인 구강편평세포암종 환자의 다단계 발암과정에서 Visfatin의 발현 분석

Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon-Kyoung Bae, Mi Heon Ryu, Soo-Kyung Bae
  • 언어ENG
  • URLhttp://db.koreascholar.com/Article/Detail/299464
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대한구강악안면병리학회지
제39권 제2호 (2015.04)
pp.479-486
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Visfatin is a pro-inflammatory cytokine, which is thought to play a central role in systemic inflammation and the pathogenesis of obesity related diseases. Only a few studies investigated the effect of visfatin on human cancers. Furthermore, there have been no studies on the association between the expression of visfatin in OSCC tissue and its effect on OSCC patients. Hence, the present study analyzed the expression of visfatin in OSCC from Korean patients. Immunohistochemistry for visfatin was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakias (with/without dysplasia), and 58 OSCC patients samples. Immunoreactivity was semi-quantitatively scored and the correlation between the expression of visfatin and clinicopathological parameters of OSCC patients was analyzed. The immunohistochemical analysis demonstrated that the expression level of visfatin increased in OSCC alone (p<0.05). Moreover, the immunoexpression score of visfatin was significantly correlated with TNM stage of OSCC patients. Our findings suggested that visfatin can play a certain role in the pathogenesis of OSCC. In addition, visfatin was associated with the tumor progression of OSCC patients and may act as independent biomarker of OSCC.

키워드
Oral Squamous Cell CarcinomaVisfatinAdipocytokineTumor ProgressionBiomarker
목차
 Ⅰ. INTRODUCTION
 Ⅱ. MATERIALS AND METHODS
  1. Patients and tissue specimens
  2. Immunohistochemical stain for visfatin
  3. Evaluation of immunohistochemical stain
  4. Statistical Analysis
 Ⅲ. RESULTS
  1. Immunohistochemical stain for visfatin
  2. Correlation between visfatin and the clinicopathologicalparameters of OSCC patients
  3. Correlation between visfatin and NF-kB p65 inOSCC patients
 IV. DISCUSSION
 V. REFERENCES
저자
  • Se-Ra Park(Department of Dental Pharmacology, School of Dentistry) | 박세라
  • Hye-Yeon Han(Department of Oral Pathology, School of Dentistry, Institute of Translational Dental Sciences) | 한혜연
  • Jiyeon Kim(Department of Pediatric Dentistry, School of Dentistry, Dental Research Institute) | 김지연
  • Moon-Kyoung Bae(Department of Oral Physiology, School of Dentistry4), Pusan National University Busandaehak-ro 49, Mulgeum-eup, Yangsan, Gyeongsangnam-do, Korea, Republic of, 626-870, South Korea) | 배문경
  • Mi Heon Ryu(Department of Oral Pathology, School of Dentistry, Institute of Translational Dental Sciences) | 유미현 Corresponding author
  • Soo-Kyung Bae(Department of Dental Pharmacology, School of Dentistry) | 배수경 Corresponding author