KOREASCHOLAR

The process 0 1' wound healing needs the deposition of collagen and non-collagenous compounds, followed by the remodelling of extracellul ar matrix Recently, it has known that LEDs irradiation can help wound healing to accelerate the cell proliferation. But its mec hanism is not elucidated yot. The purpose of the present study is to observe the expression level of extracellular matrix by 635nm LEDs ir radiation. Human gingival fibroblasts were primary cultured, treated arac hidonic acid (때 and followed by LEDs irradiation. To observe the mRNA expression of extracellular matrix, cDNA mlcroarray was ca n‘ ied out 1n present study, 3 experimental groups were categorized into control, AA-treated group, and AA-treated with LEDs irradiation group. The differential expressions of MMP-1, -2, -3, - 10, - 11, -14, -16, - 17, -25 and TIMP-1, -2, -3. -4 were observed. Especially, mRNA expression of T1MP-3 was 10 fold decreased in arach idonic acid -treated with 635nm LEDs irradiation group. Finally, LEDs irradation can affect the expression level of MMPs and TIMPs, which lead to prolifer ation of gingival fibroblasts and result in would healing

• 김형수(전남대학교 치의학연구소) | Hyoung Su Kim
• 정민아(전남대학교 치의학연구소) | Min A Chung
• 임원봉(전남대학교 치의학연구소) | Won Bong Lim
• 조진형(전남대학교 치과대학 교정학교실) | Jin Hyoung Jo
• 김미숙(전남대학교 치의학연구소) | Mi Suk Kim
• 김옥준(전남대학교 치의학연구소) | Ok Joon Kim
• 최홍란(전남대학교 치의학연구소) | Hong Ran Choi Correspondence