KOREASCHOLAR

Sprague-Dawley Rat에서 RK3E-ras Cell의 주입에 의한 악성 종양의 유도 Rapid Induction of Malignant Tumor in Sprague-Dawley Rats by Injection of RK3E-ras Cells

김현우, 김수아, 안상건, 윤정훈
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  • URLhttp://db.koreascholar.com/Article/Detail/324655
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대한구강악안면병리학회지
제30권 제2호 (2006.04)
pp.81-87
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells(RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague-Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.

키워드
RK3Ek-rastumor modelSprague-Dawley rat
저자
  • 김현우(조선대학교 치과대학 구강병리학교실, BK 21) | Hyun-Woo Kim
  • 김수아(조선대학교 치과대학 구강병리학교실, BK 21) | Soo A Kim
  • 안상건(조선대학교 치과대학 구강병리학교실, BK 21) | Sang Gun Ahn
  • 윤정훈(조선대학교 치과대학 구강병리학교실, BK 21) | Jung Hoon Yoon Correspondence