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구강캔디다증 환자의 항진균 치료 Antifungal Therapy in Patient with Oral Candidiasis

김해영, 강재국, 임영관, 김병국, 김혜은, 조혜중, SUNQIAOCHU, 안규현, SHISHUHAN, 김옥준
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대한구강악안면병리학회지
제41권 제2호 (2017.04)
pp.79-89
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

The aim of this study was to examine the effects and the sensitivity of antifungal therapy for patients with oral candidiasis and to investigate the relationship among the signs & symptoms of patients and the ratio change of Candida species to antifungal therapy. Candida fungus culture test with ChromeIDTM Candida agar (CAN2) was carried out more than twice for 10 patients who visited Oral Medicine department of Chonnam National University Dental Hospital during the period from Dec. 2015 to Aug. 2016. After culturing the smear sample before and after antifungal therapy in ChromeIDTM Candida agar (CAN2), the number of colonies was counted to compare. Patients were divided into 5 group according to the therapeutic effects of the antifungal agents used: 1) high susceptibility to nystatin, 2) low susceptibility to nystatin, 3) high susceptibility to fluzonazole, 4) low susceptibility to fluzonazole, and 5) increased ratio of new Candida species. Although nystatin is used as first-line therapy in oral candidiasis, it is desirable to use fluconazole if patients had a history of the low sensitivity to nystatin or chemotherapy. Even if the patient's symptoms and signs are improved, there is a possibility of oral candidiasis recurring, so that clinicians should be careful during the treatment with antifungal agents.

키워드
Antifungal therapyOral candidiasisSmear
저자
  • 김해영(전남대학교 치의학전문대학원 구강병리학교실,) | Hae Yong Kim (Dental Research Institute, Department of Oral Pathology,)
  • 강재국(전남대학교 치의학전문대학원 구강병리학교실,) | Jae Kook Kang (Dental Research Institute, Department of Oral Pathology,)
  • 임영관(전남대학교 치의학전문대학원 구강내과학교실) | Yeong Gwan Im (Department of Oral medicine School of Dentistry, Chonnam National University.)
  • 김병국(전남대학교 치의학전문대학원 구강내과학교실) | Byung Gook Kim (Department of Oral medicine School of Dentistry, Chonnam National University.)
  • 김혜은(전남대학교 치의학전문대학원 구강병리학교실,) | Hye Eun Kim (Dental Research Institute, Department of Oral Pathology,)
  • 조혜중(전남대학교 치의학전문대학원 구강병리학교실,) | Hye Joung Cho (Dental Research Institute, Department of Oral Pathology,)
  • SUNQIAOCHU(전남대학교 치의학전문대학원 구강병리학교실,) | SUN QIAOCHU (Dental Research Institute, Department of Oral Pathology,)
  • 안규현(전남대학교 치의학전문대학원 구강병리학교실,) | Kyu Hyeon Ahn (Dental Research Institute, Department of Oral Pathology,)
  • SHISHUHAN(전남대학교 치의학전문대학원 구강병리학교실,) | SHI SHUHAN (Dental Research Institute, Department of Oral Pathology,)
  • 김옥준(전남대학교 치의학전문대학원 구강병리학교실,) | Ok Joon Kim (Dental Research Institute, Department of Oral Pathology,) Corresponding author