The purpose of this study was to investigate meteorological factors’ effects on clothing sales based on empirical data from a leading apparel company. The daily sales data were aggregated from “A” company’s store records for the Fall/Winter season from 2012 to 2015. Daily weather data corresponding to sales volume data were collected from the Korea Meteorological Administration. The weekend effect and meteorological factors including temperature, wind, humidity, rainfall, fine dust, sea level pressure, and sunshine hours were selected as independent variables to calculate their effects on A company’s apparel sales volume. The analysis used a SAS program including correlation analysis, t-test, and multiple-regression analysis. The study results were: First, the weekend effect was the most influential factor affecting sales volume, followed by fine dust and temperature. Second, there were significant differences in the independent variables’effects on sales volume according to the garments’ classification. Third, temperature significantly affected outer garments’sales volume, while top garments’ sales volume was not influenced significantly. Fourth, humidity, sea level pressure and sunshine affected sales volume partly according to the garments’ item. This study can provide proof of significant relationships between meteorological factors and the sales volume of garments, which will serve well to establish better inventory strategies.