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4-Nonylphenol이 조피볼락의 난황단백질 합성에 미치는 영향 Effect of 4-Nonylphenol on Vitellogenesis in the Juvenile Rockfish, Sebastes schlegeli

황운기, 최옥인, 허승, 안경호, 박종수
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해양환경안전학회 학술대회 논문집
2010년도 (사)해양환경안전학회 추계학술발표회 논문집 (2010.11)
pp.231-234
해양환경안전학회 (The Korean Society Of Marine Environment & Safety)
Abstract

n re cent ye ars, remarkable conce rn has be en eme rged ove r endocr ine disrupting chemicals (E D Cs) which mimic the e ffe cts of the ste roid hormone and modulate the endocr ine functions of human and wildlife . The biodegradation products of sur factants such as nonylphenol (N P ) have be en regarded as E D Cs. H oweve r , only few studie s have be en car r ied out to inve stigate the e ffe ct of E D Cs on vite llogene sis in mar ine fish. The pre sent study was unde r taken to the e ffe cts of 4-N P on the vite llogene sis of juvenile rockfish, Sebaste s schlege li. J uvenile rockfish we ighing about 50g we re intrape r itone ally inje cted with e stradiol-17β (E 2, 5㎎/㎏ body we ight) or 4-N P in 70% e thanol twice at 3-day inte rvals and blood sampling we re extracted from the fish at 7 days afte r the last inje ction. I ntense VTG bands we re de te cted at mole cular we ight position of about 170kD a in all the plasma of 4-N P -administrated fish as that of E 2-administe red fish. P lasma ALP P , Ca and GP T concentrations we re also incre ased in all the group of 4-N P -administe red fish. The addition of 4-N P to the we lls inhibited the binding activity E 2 to E R in a conve rse sigmoid fashion. The se re sults sugge sted that 4-N P induced VTG synthe sis by the binding affinity 4-N P to E R and acted on E D Cs in the juvenile rockfish

Author
  • 허승(서해수산연구소) | Seung Heo (West Sea Fisheries Research Institute /WSFRI, Incheon 400-420, Korea)
  • 안경호(서해수산연구소) | Kyoung-Ho An (West Sea Fisheries Research Institute /WSFRI, Incheon 400-420, Korea)
  • 박종수(서해수산연구소) | Jong-Soo Park (West Sea Fisheries Research Institute /WSFRI, Incheon 400-420, Korea)
  • 최옥인(서해수산연구소) | Ok-In Choi (West Sea Fisheries Research Institute /WSFRI, Incheon 400-420, Korea)
  • 황운기(서해수산연구소) | Un-Gi Hwang (West Sea Fisheries Research Institute /WSFRI, Incheon 400-420, Korea)