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Stage Ⅱ 약물유발 악골괴사(MRONJ)에서 외과적 치료법이 갖는 효용성 Usability of Surgical Treatment of Stage Ⅱ Medication Related Osteonecrosis of the Jaw

황대석, 송재민, 유미현, 최나래
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  • URLhttp://db.koreascholar.com/Article/Detail/367169
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대한구강악안면병리학회지
제43권 제1호 (2019.02)
pp.17-26
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

This study was planned to evaluate the efficacy of surgical treatment in stage 2 medication related osteonecrosis of jaw(MRONJ) patients. Retrospective analysis was performed about patients who were treated with medication related osteonecrosis of jaw from 2015 to 2017. 25 Patients were treated by a single surgeon at the Department of Oral Surgery, Dental Hospital, Pusan National University. The treatment methods they received were conservative or surgical. The results of treatment were classified as "fail" and "success" and the prognosis according to the treatment method was compared. Conservative treatment 14.29% (2 cases), sequestrectomy 64.29% (9 cases) and saucerization 21.43% (3 cases) were performed in the MRONJ group, and 2 treatment failures were encountered after conservative treatment and 1 after saucerization. Surgical treatment resulted in better outcomes in stage 2 MRONJ patients. Furthermore, treatments were deemed successful when surrounding necrotic bone containing sequestrum was reliably removed. Therefore, this study suggests that the treatment of "stage 2" MRONJ should actively consider surgical treatment.

키워드
Medication related osteonecrosis of jawMRONJStage 2Surgical treatmentUsability
목차
Abstract
 Ⅰ. INTRODUCTION
 Ⅱ. MATERIAL and METHODS
  1. Patients
  2. Treatment methods
  3. Statistical analysis
 Ⅲ. RESULTS
  1. Age and gender
  2. Methods and durations of antiangiogenic or antiresorptive agent treatment in the MRONJ group
  3. Underlying disease in the non-MRONJ group
  4. Causes of jaw necrosis
  5. Location of jaw necrosis
  6. Treatment methods
  7. Treatment outcomes
  8. Histopathologic Finding
 Ⅳ. DISCUSSION
 REFERENCES
저자
  • 황대석(부산대학교 치의학전문대학원 구강악안면외과학 교실) | Dae-Seok Hwang (Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 송재민(부산대학교 치의학전문대학원 구강악안면외과학 교실) | Jae-Min Song (Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 유미현(부산대학교 치의학전문대학원 구강병리학 교실, BK21 플러스) | Mi-Heon Ryu (Dept. of Oral Pathology, BK21 Plus project, School of Dent istry, Pusan National University)
  • 최나래(부산대학교 치의학전문대학원 구강악안면외과학 교실) | Na-Rae Choi (Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) Correspondence