KOREASCHOLAR

구강암 환자의 생존율과 관련된 임상 영향인자들과 암 호발 항원단백인자 조사 Screening on ATG-Antigen Protein Related with Survival Rate on Clinicopathologic Factors in OSCC Patients

유미현, 장민아, 김욱규
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  • URLhttp://db.koreascholar.com/Article/Detail/405766
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대한구강악안면병리학회지
제45권 제1호 (2021.02)
pp.1-10
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Autophagy is a cell survival mechanism that works for the survival of cells under various physiological and pathological conditions. ATG5 is a key protein in the process of autophagy propagation and is involved in tumor development and progression. Chemotherapeutic agents targeting ATG5 enhance the host's immune response in various human cancers and intensify the effectiveness of chemotherapy. However, the physiological role of ATG5 protein in oral squamous cell carcinoma (OSCC) has not been fully recognized. The purpose of this study was to examine the correlation between clinico-pathological factors of OSCC patients and ATG5 immunoexpression through immunohistochemistry (IHC) in the tissues of OSCC patients treated at our hospital, and to analyze the regarding influences and their mechanisms. The authors analyzed 20 OSCC patients from National University Dental Hospital, at Pusan National University from January 2002 to December 2007, which were eligible for the study. Data were obtained by reviewing the medical records of the OSCC patients, and ATG5 immunoexpression was obtained using IHC staining in the tissue samples of the OSCC patients. In the tissue sample of OSCC patients, the immunoexpression of ATG5 elevated, in comparison to the normal oral mucosa, and there was a significant correlation with Drinking, Pathological Stage. In regards to Cox regression analysis, Clinical stage, Tumor size, Histopathologic grade, Cervical nodal metastasis, Loco-regional recurrence, and ATG5 expression have statistically significant correlations. These results imply that the changes in the expression of ATG5 proteins in OSCC can be a prominent factor in the OSCC progression and the prognosis of OSCC patients.

키워드
ATG5AutophagyOral squmous cell carcinomaImmunohistochemistryBiomarker
목차

Ⅰ. INTRODUCTION
Ⅱ. SUBJECTS AND METHODS
    1. Tissue samples of OSCC patients
    2. Histological review of tissue samples
    3. The analysis of clinico-pathological factorsof OSCC patients
    4. Reagents and antibodies
    5. ATG5 Immunohistochemical staining oftissue samples
    6. Statistical analysis
Ⅲ. RESULTS
    1. Characteristics of the OSCC patients
    2. The difference in the expression of ATG5protein
    3. Correlation with the clinico-pathologicalfactors of OSCC patients
    4. Cox regression and Kaplan-Meier survivalgraph analysis
Ⅳ. DISCUSSION
Ⅴ. CONCLUSIONS
REFERENCES
저자
  • 유미현(부산대학교 치의학전문대학원 구강병리학 교실/부산대학교 치의생명과학 교육연구팀/치의생명과학연구소) | Mi Heon Ryu (Department of Oral Pathology, Education and Research Team for Life Science on Dentistry/Dental and Life Science Institute, School of Dentistry, Dental and Life Science Institute, Pusan National University)
  • 장민아(부산대학교 치의학전문대학원 구강병리학 교실/치의생명과학연구소) | MinA Jang (Department of Oral Pathology, School of Dentistry, Pusan National University)
  • 김욱규(부산대학교 치의학전문대학원 구강악안면외과학 교실) | Uk-Kyu Kim (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) Correspondence