This study aims to determine the difference in preferred horticultural plants, horticultural activities, and stress-coping strategies based on Enneagram centers of intelligence in middle-aged women. Data from a convenience sample of 206 middle-aged women were analyzed using IBM SPSS (V. 25.0). The results indicated a statistically significant difference in preferred horticulture plants depending on the Enneagram centers of intelligence. The results also suggested that head- and heart-centered respondents preferred body-centered respondents preferred “foliage plants.” The second most preferred horticultural activities showed no statistically significant difference among the head, heart, and body. However, all three centers showed the strongest preference for “enjoying” among various horticultural activities, and the second most preferred activities differed as “harvesting” among head- and body-centered respondents, and “decorating” among heart-centered respondents. Moreover, a difference in stress-coping strategies was also observed. The head-centered respondents used the “problem-focused” strategy, heart-centered respondents used “hopeful thinking,” and the body-centered respondents used “pursuit of social support.” Thus, these results can be used as baseline data for developing therapeutic horticultural activities while considering the attributes of middle-aged women.