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혀에 발생한 전이성 미분화다형태육종 증례 보고 Metastatic Undifferentiated Pleomorphic Sarcoma on Tongue: Case Report

김윤현, 홍진호, 정재환, 김현민, 한승용, 김현실, 김형준
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대한구강악안면병리학회지
제46권 제5호 (2022.10)
pp.105-109
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Sarcoma is rare malignant tumors that develop from mesenchymal cells. Metastasis to the oral cavity is a rare occurrence. Undifferentiated Pleomorphic sarcoma(UPS), formerly known as Malignant fibrous histiocytoma(MFH), is rare spindle cell neoplasm that can have poorly prognosis with metastasis and local recurrence. This report describes a case of a 77-year-old man who was diagnosed with Undifferentiated Pleomorphic Sarcoma of the chest wall and underwent adjuvant radiation therapy after surgical resection. Although there was success of wide excision, two years later, he presented with metastasis to the several organs including tongue. We retrospectively analyzed results of Next Generation Sequencing(NGS), and we figured out RB1 gene mutation. Until now targeted therapy of RB1 gene mutation is not established. Surgeon needs to consider metastatic tumors through identifying patients’ chief complaints and past medical & dental history. We need to research through NGS, and take a step closer to find targeted therapy for tumors.

키워드
UPSUndifferentiated Pleomorphic SarcomaRB1Tongue metastasisMetastatic sarcoma
목차
Abstract
Ⅰ. INTRODUCTION
Ⅱ. CASE REPORT
Ⅲ. DISCUSSION
Ⅳ. CONCLUSION
REFERENCES
저자
  • 김윤현(연세대학교 치과대학 구강악안면외과학교실) | Yoon Hyeon Kim (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 홍진호(연세대학교 치과대학 구강악안면외과학교실) | Jin-Ho Hong (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 정재환(연세대학교 치과대학 구강악안면외과학교실) | Jae Hwan Jung (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 김현민(연세대학교 치과대학 구강악안면외과학교실) | Hyounmin Kim (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 한승용(연세대학교 치과대학 구강병리학교실) | Seung-Yong Han (Department of Oral Pathology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 김현실(연세대학교 치과대학 구강병리학교실) | Hyun Sil Kim (Department of Oral Pathology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 김형준(연세대학교 치과대학 구강악안면외과학교실) | Hyung Jun Kim (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea) Corresponding author