In this paper, a numerical study was conducted on the development of HVAC(Heating, Ventilating and Air Conditioning) performance required for a large-scale greenhouse. In order to increase the simulation efficiency, fan model, porous media, and radiator model, etc. provided by Fluent were used based on the part performance analysis such as blowing fans and PTC heaters. Developed simulation method was applied to the decision of fan position to secure the flow uniformity and the determination of the heater specification to maintain the temperature suitable for plant growth. This study is the first step for the development of integrated environmental control system of greenhouse for high-income crop cultivation and the simulation method will be revised after correlation test.