Purpose: Even today, cancer remains a challenge to overcome. The purpose of this study is to understand the current status of lip-oral-pharyngeal cancer in Koreans by identifying the survival rate of lip-oral-pharyngeal cancer in Koreans through long-term big data. Material and Method: This study utilized 2023 KOSIS (Cancer Registration Statistics, Ministry of Health and Welfare) academically. The 5-year relative survival rates of lip-oral-pharyngeal cancer from 1996 to 2020 were compared and analyzed at 5-year intervals. Results: The 5-year relative survival rate for lip-oral-pharyngeal cancer was 47.4% from 1996 to 2000, 54.5% from 2001 to 2005, 61.1% from 2006 to 2010, 65.5% from 2011 to 2015, and 69.7% from 2016 to 2020. From 1996 to 2005, the 5-year relative survival rate for lip-oral-pharyngeal cancer was higher than the 5-year relative survival rate for all cancers. However, in the recent 15 years from 2006 to 2020, the 5-year relative survival rate for lip-oral-pharyngeal cancer was lower than for all cancers. Conclusions: In conclusion, this long-term big data showed that the 5-year relative survival rate of lip-oral-pharyngeal cancer in Koreans has increased further in modern times. However, in order to increase the overall survival rate of all human cancers, continuous efforts to improve the survival rate of lip-oral-pharyngeal cancer are needed in the future.