This study investigates the gap between statutory calculation standards and actual field conditions in estimating Occupational Safety and Health Management Expenses (OSHME) for large-scale construction projects. The current fixed-rate method, based on construction type and cost, fails to account for on-site factors such as project complexity, duration, and workforce structure, often leading to discrepancies between estimated and actual costs. To address this, data from 21 completed projects over KRW 5 billion were analyzed. Multiple regression analysis was conducted using variables including material and labor costs, project duration, floor area, number of floors, and the number of safety personnel. The results showed a significant statistical difference between calculated and actual OSHME, and the proposed model explained 95.3% of the variance (R2 = 0.953). Variable selection techniques were applied to improve prediction accuracy by addressing multicollinearity. The model offers practical value for early budgeting and supports policy improvements that align safety expenses with real on-site needs, in order to more effectively prevent industrial accidents.