Polymer gel implant for soft tissue augment is demanded biological safety properties. This study is designed process and equipment producing for obtain micro bead using the hyaluronic acid water solution. This equipment is composed of cooling pipe, air pump, dispenser and process is consecutive/simple for preservation from environmental contamination. Besides, without difficulty remove the residual agent after crosslink. We evaluate to in vitro cytotoxicity test for verification of hyaluronic acid gel obtained by this equipment and process. This product is "non cytotoxcity" from the result of evaluation cytotoxcity test.

Abstract
 1. 서 론
 2. 장치 및 공정
  2.1 고분자수용액 방울 생성장치
  2.2 가교된 고분자구슬 제조방법
 3. In vitro 세포독성 평가
 4. 결과 및 고찰
 5. 결 론
 참 고 문 헌

• 김진태(충북대학교 신소재공학과) | J. T. KIM
• 국창호(중앙대학교 기계공학부) | C. H. KOOK
• 최재하(충북대학교 신소재공학과) | J. H. CHOI