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초고압 가공 공정을 통한 지치 추출물의 항암 활성 증진 KCI 등재

Enhancement of Anticancer Activities from Lithospermum erythrorhizon Extracts by Ultra High Pressure Process

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한국약용작물학회지 (Korean Journal of Medical Crop Science)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

This study was performed to enhance anticancer activities of Lithospermum erythrorhizon by eluting high amount of shikonin through ultra high pressure process. Extraction yield was increased up to 5~10% by ultra high pressure process, compare to the normal extraction processes such as water solvent extraction, 70% ethyl alcohol solvent extraction. The cytotoxicity of the extracts (1.0μg/ml) from ultra high pressure process was showed the lowest cytotoxicity 13.4% for human lung cell (HEL299). The anticancer activities showed 80~85% by adding 1.0μg/ml of the extracts from ultra high pressure process in several cancer cell lines such as AGS, Hep3B, MCF-7 and HeLa cells. Among them, MCF-7 cell of the endocrine system was highest inhibited than other cells. The anticancer activities of the extracts from ultra high pressure extraction process showed 10~15%, which was higher than the extracts from normal extraction processes. From HPLC analysis of the extracts, the contents of shikonin in the extracts from ultra high pressure process was 11.42% (w/w), which was 20% higher than others. This results indicate that ultra high pressure process could increase the extraction yield of shikonin and other contents, which resulted in higher anticancer activities.

저자
  • 서용창 | Seo, Yong-Chang
  • 최운용 | Choi, Woon-Yong
  • 김지선 | Kim, Ji-Seon
  • 조정섭 | Cho, Jeong-Sub
  • 김영옥 | Kim, Young-Ock
  • 김진철 | Kim, Jin-Chul
  • 이현용 | Lee, Hyeon-Yong