MYC (v-myelocytomatosis viral oncogene homologue) is a regulator gene that encodes for a nuclear phosphoprotein. Porcine MYC gene was mapped on chromosome SSC 4p13 and is associated with a variety of functions such as cell proliferation and cell growth. MYC expression is coupled to a multitude of physiological processes and is regulated by hormones, growth factors, cytokines, lymphokines, nutritional status, development and differentiation. MYC is also involved in myogenesis, muscle hyperplasia and adipogenesis. In this study, we investigated SNPs in MYC gene and their association with economic traits in Duroc, Landrace and Yorkshire populations. We detected a single point mutation in exon 3 of porcine MYC gene as a change of T to C at 906 base (amino acid position 302, nonsynomous mutation of alanine) in MYC-N domain. MYC mutation (T906C) was significantly associated with age at 90 kg in these breeds, signifying that this mutation can serve as a selection marker for growth traits in pigs.

• Jae-Don Oh(Genomic Informatics Center, HanKyong National University)
• Ki-Duk Song(Genomic Informatics Center, HanKyong National University)
• Roxan Grace Caccho(Genomic Informatics Center, HanKyong National University)
• Jiyeon Seong(Genomic Informatics Center, HanKyong National University)
• Eun-Ji Choi(Genomic Informatics Center, HanKyong National University)
• Myungsang Yu(National Agricultural Federation Pig Breeding Center)
• Kyoungtae Kim(National Agricultural Federation Pig Breeding Center)
• Tae-Hun Kim(Genomic Informatics Center, HanKyong National University)
• Sung-Hoon Kim(Genomic Informatics Center, HanKyong National University)
• Eui-Soo Kim(Genomic Informatics Center, HanKyong National University, Department of Animal Science, Iowa State University)
• Hak-Kyo Lee(Genomic Informatics Center, HanKyong National University)
• Hong-Sik Kong(Genomic Informatics Center, HanKyong National University) Corresponding author