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Growth Rate of Transgenic Pigs and Size of Pig Hearts for Xenotransplantation to Cynomolgus Monkey KCI 등재

  • 언어ENG
  • URLhttps://db.koreascholar.com/Article/Detail/286385
  • DOIhttps://doi.org/10.12750/JET.2014.29.4.333
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한국동물생명공학회지 (구 한국수정란이식학회지) (Journal of Animal Reproduciton and Biotechnology)
한국동물생명공학회(구 한국수정란이식학회) (Journal of Animal Reproduction & Biotechnology)
초록

To compensate for the critical shortage of human organs for allotransplantation, xenotransplantation studies using genetically modified pigs are being performed in Korea. Two types of pigs that are used are α1,3-galactosyltransferase gene knockout (GalT KO) pigs and GalT KO+hCD46 (human complement regulatory protein) pigs. The present study measured the gestation time, birth weight, daily growth rate, and heart weight of both kinds of transgenic minipigs. The gestation period for both types of pigs was 117∼119 days. There was no difference in the body weight of GalT KO (—/+) and GalT KO (—/—) piglets, but GalT KO+hCD46 (—hCD46+/+) pigs were significantly heavier at birth than were GalT KO+hCD46 (—hCD46+/—hCD46+) pigs. During the first 10 weeks of life, the daily weight gain of GalT KO+hCD46 (—hCD46+/—CD46+) piglets, which are considered the optimal type for xenotransplantation, was 0.19 kg. The weight of hearts from GalT KO piglets up to two months of age was affected more by body weight than by age. Transgenic pigs showed no differences in gestation period or reproductive ability compared with normal pigs. These results comprise basic data that may be used in xenotransplantation studies and transgenic animal production in Korea.

저자
  • Sun A Ock(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration) Corresponding author
  • Keon Bong Oh(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Seongsoo Hwang(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Jungkyu Lee(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Youngim Kim(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Sun-Woung Moon(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Dae-Jin Kwon(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)
  • Ik Jin Yun(Department of Surgery, Konkuk University School of Medicine)
  • Eungwoo Park(Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration)