It is necessary to improve the esthetic and function in the patient with oral and maxillofacial bone defects. Synthetic bone substitute materials and anorganic bovine bone mineral(ABBM) have been used for clinical restoration. The purpose of this study was to observe the biocompatibility and bone formation of synthetic hydroxyapatite(SHA) and ABBM in hole of rabbit's tibia. After specimens with SHA and ABBM at 8 weeks were fixed in 10% neutral formalin solution, dehydrated, and embedded with spurr low viscosity, they were cut by 500um with slow diamond wheel saw and grinded up to 200um in thickness. These specimens were coated with carbon and examined with r efraction microscope for bone density. Refraction microscopic features of 8 weeks in synthetic HA showed network-like new bone forming trabecular pattern attached to resorbed HA. Less well calcified trabecular bone surrounding conglomerated HAs showed irregular arrangement of numerous osteocytes. There was not completely filled in defected area by new bone trabecular. New trabecular bone formation by ABBM was more prominent and completely compacted in defect hole at 8 weeks. It suggested that although bone formation activity of AMMB might be superior to that on synthetic HA, both group would be the good biocompatibility in this experiment.

I. 서론
 II. 연구재료 및 방법
  1. 수산화인회석 합성
  2. 골 결손부 형성과 ABBM 및 수산화인회석 매입과반사전자현미경 관찰
 III. 연구결과
 IV. 총괄 및 고찰
 V. References

• 이석준(단국대학교 체육대학) | Suk Joon Lee correspondence