논문 상세보기
pp.109-116
The HWND_G02 (Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino) and HWND_G03 (Cinnamonum cassia Blume, Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino, Allium macrostemon Bunge) are new natural mixture composed with several oriental herbs. The aim of the present study was to investigate the effects of HWND extracts on high cholesterol diet (HCD)-induced hyperlipidemic rats. Male Sprague-Dawley rats were divided into five groups: control, HCD, atorvastatin (5 ㎎/㎏, po), ethanolic extracts of HWND_G02 (1,000 ㎎/㎏, po) and HWND_G03 (1,000 ㎎/㎏, po) were administered to the HCD-induced hyperlipidemic rats for 4 weeks to evaluate their anti-hyperlipidemic activities. HWND extracts markedly decreased body and liver wight gain, and recovered serum lipid levels, such as total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in the HCDinduced hyperlipidemic rats. Furthermore, the lipid levels (TC and TG) and the lipid accumulation were significantly lowered in the liver tissue of HWND-administrated rats. After a HCD, each group had a lower atherogenic index (AI) compared to the HCD group. In conclusion, these data suggest that HWND extracts could be the candidate for the material to prevent hyperlipidemia.
재료 및 방법
1. 시료의 조제
2. 기기 및 분석조건
3. 실험동물
4. 고지혈증 유도 및 시료투여
5. 생화학적 분석
6. 간조직의 형태학적 평가
7. 통계분석
결과 및 고찰
1. HWND_G02 및 G03의 주요성분 함량 확인
2. 고지혈증이 유발된 동물모델에서 HWND_G02 및 G03의체중 및 간 중량 변화
3. HWND_G02 및 G03에 의해 고지혈증이 유발된 동물모델의 혈액에서 지질함량 지표 및 동맥경화 지수 변화
4. HWND_G02 및 G03에 의해 고지혈증이 유발된 동물모델의 혈액에서 간 독성 지표 변화
5. HWND_G02 및 G03에 의해 고지혈증이 유발된 동물모델의 간 조직에서 지질함량 지표 변화
6. HWND_G02 및 G03에 의해 간 조직의 형태학적 및지질침착정도 변화
REFERENCES
