논문 상세보기
pp.89-97
목적: 본 연구는 2-fluoro-4-pyridinecarboxylic acid 및 6-fluoropyridine-3-carboxylic acid를 사용하여 친수성 하이드로젤 콘택트렌즈 재질을 중합하고 제조된 친수성 콘택트렌즈의 물리적, 광학적 특성을 분석하여 이들 물질들의 콘택트렌즈 재료로서의 활용도를 알아보았다. 방법: 본 연구는 카르복시산 및 불소로 치환한 피리딘을 2가지 이상 첨가제로 사용하여 친수성 콘택트렌즈의 기본적인 재질인 HEMA(2-hydroxyethyl methacrylate), AA(acrylic acid), MMA(methylme-thacrylate), 개시제인 AIBN(azobisisobutyronitrile), 그리고 교차결합제인 EGDMA(ethylene glycol dimethacrylate)를 사용하여 공중합하였다. 결과: 생성된 고분자의 물리적 특성을 측정한 결과, 굴절률 1.4348-1.4300, 함수율 33.69~35.84%, 가시광선 투과율 89.6~90.8%, 인장강도 0.2292-0.3344kgf 그리고 접촉각의 경우 76.05°~50.95°의 분포를 나타내었다. 또한 황색포도상구균에 대한 항균실험 결과 2-fluoro-4-pyridinecarboxylic acid 및 6- fluoropyridine-3-carboxylic acid를 5% 첨가했을 때 항균효과가 다소 있는 것으로 나타났다. 결 론: 본 실험 결과, 2-fluoro-4-pyridinecarboxylic acid 및 6-fluoropyridine-3-carboxylic acid를 첨가하여 제조된 친수성 콘택트렌즈는 기본적인 콘택트렌즈 물성을 만족하였으며 우수한 습윤성과 항균성 및 자외선 차단 콘택트렌즈로 활용될 수 있을 것으로 판단된다.
Purpose: This study evaluated the physical and optical characteristics of hydrophilic contact lens polymerized with addition of 2-fluoro-4-pyridinecarboxylic acid and 6-fluoropyridine-3-carboxylic acid in the basic hydrogel contact lens material, and in particular, the utility of 2-fluoro-4-pyridinecarboxylic acid and 6-fluoropyridine-3-carboxylic acid as a contact lens material for ophthalmologic devices was investigated. Methods: In this study 2-fluoro-4-pyridinecarboxylic acid and 6-fluoropyridine-3-carboxylic acid were used as additives. 2-Hydroxyethyl methacrylate, methyl methacrylate, acrylic acid and a cross-linker EGDMA were copolymerized in the presence of AIBN as an initiator. Results: The physical properties of the produced polymers were measured as followings. The refractive index of 1.4348~1.4300, water content of 33.69~35.84%, visible transmittance of 89.6~90.8%, tensile strength of 0.2292~0.3344kgf, and contact angle of 76.05°~50.95°were obtained. The results of contact lens containing 2-fluoro-4-pyridinecarboxylic acid and 6- fluoropyridine-3-carboxylic acid (add 5%) showed antibiosis for staphylococcus aureus. Result: Based on the results of this study, contact lens material containing 2-fluoro- 4-pyridinecarboxylic acid and 6-fluoropyridine-3-carboxylic acid is expected to be able to be used usefully as a material for high wettability, antibiosis and UV-block hydrogel contact lens.
