Embryo reconstruction by somatic cell nuclear transfer (SCNT) has been used to demonstrate that mammalian somatic cells can dedifferentiate into a totipotent nucleus when introduced into an oocyte. This process of dedifferentiation of somatic cells after nuclear transplantation is defined as nuclear reprogramming, although this terminology gives little information on the molecular events that characterize this process. When planning on strategies for nuclear reprogramming by nuclear transfer (NT) one may suggest that converting the somatic nuclear configuration into an embryonic state is highly desirable, so this may promote a succession of events similar to those occurring during early embryo development. In the following part of this overview we will discuss the results of many studies that have investigated different aspects of nuclear remodelling after SCNT.

• Joon-Hee Lee(Department of Animal Bioscience, College of Agriculture and Life Sciences, Gyeongsang National University,3Institute of Agriculture & Life Science, College of Agriculture and Life Sciences, Gyeongsang National University) Corresponding author
• Yeoung-Gyu Ko(Animal Genetic Resources Station, National Institute of Animal Science, Rural Development Administration,)
• Sung-Woo Kim(Animal Genetic Resources Station, National Institute of Animal Science, Rural Development Administration)
• Soo-Bong Park(Animal Genetic Resources Station, National Institute of Animal Science, Rural Development Administration)