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시스플라틴으로 유발된 신장독성 마우스에서 잇꽃씨 폴리페놀의 신장 보호 효과

Renoprotective Effects of Polyphenols of Safflower Seed in the Cisplatin-Induced Nephrotoxicity Mice

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  • URLhttps://db.koreascholar.com/Article/Detail/326785
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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : In this study, we investigated the renoprotective effects of serotonin and its derivatives, on the renal function and expression of inflammation and apoptosis in cisplatin-induced nephrotoxicity mice. Methods and Results : Serotonin and its derivatives were orally administered at a dose of 7.5 mg/kg body weight for 5 days before the intraperitoneal injection of cisplatin 20 mg/kg body weight, and the effects were compared with those of vehicle-treated nephrotoxicity control and normal groups. In the serum and kidney, renal function parameters, reactive oxygen species and expression of protein related to pro-oxidant, antioxidant, inflammation and apoptosis were examined. As a result, serotonin and its derivatives administrations to nephrotoxicity mice lowered serum BUN and creatinine concentrations. These results were derived, at least in part, from attenuation the expression of antioxidant enzymes-related proteins, SOD and GPx. In the cisplatin-induced renal condition, augmented p-p38, p-ERK and p-JNK (mitogen-activated protein kinase pathway) were reduced with a increase in antioxidant enzymes on serotonin and its derivatives treatment. Moreover, in the serotonin and its derivatives-treated groups, NF- κB-induced inflammatory factors and apoptotic protein expressions were regulated in the kidney. Conclusion : The present study indicates that serotonin and its derivatives exerts a renoprotective effect against cisplatin-induced nephrotoxicity through the recovery of kidney function deterioration and attenuation of renal inflammation and apoptosis by regulating oxidative stress condition.

저자
  • Chan Hum Park(National Institute of Horticultural and Herbal Science, RDA) | 박찬흠
  • Eun Suk Lee(Graduate School of Science and Engineering for Research, University of Toyama) | 이은숙
  • Chun Geun Park(National Institute of Horticultural and Herbal Science, RDA) | 박춘근
  • Takako Yokozawa(National Institute of Horticultural and Herbal Science, RDA Graduate School of Science and Engineering for Research, University of Toyama) | 요코자와 타카코
  • Yu Su Shin(National Institute of Horticultural and Herbal Science, RDA) | 신유수 Corresponding author