Various bioactive substances are found in mistletoe, including viscumneoside III (1) and homoflavoyadorinin B (2), both which inhibit tyrosinase. These two compounds are mainly found in the EtOAc fraction of the mistletoe extract and demonstrate higher rates of tyrosinase inhibition than ascorbic acid, which was used as a control. Our results suggest that mistletoe extracts can be utilized in skin whitening cosmetics.

• Cheolson Park(Department of Bio-Health Technology, Kangwon National University, Chuncheon 24341, Korea)
• Jaehyun Kim(Department of Bio-Health Technology, Kangwon National University, Chuncheon 24341, Korea)
• Woonsang Hwang(Department of Bio-Health Technology, Kangwon National University, Chuncheon 24341, Korea)
• Bo Duk Lee(Department of Bio-Health Technology, Kangwon National University, Chuncheon 24341, Korea)
• Kooyeon Lee(Department of Bio-Health Technology, Kangwon National University, Chuncheon 24341, Korea 2 Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Korea)