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담낭암에 대한 다학제 치료 KCI 등재 SCOPUS

Multidisciplinary Therapeutic Approach to Gallbladder Cancer

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대한췌담도학회지 (Korean Journal of Pancreas and Biliary Tract)
대한췌장담도학회(구 대한췌담도학회) (Korea PancreatoBiliary Association)
초록

담낭암은 예후가 나쁜 암종이지만 초기에 수술 치료는 매우 효과적이며 진행된 병기라도 방사선 또는 항암 방사선 병합요법이 예후를 향상시키는데 도움이 될 수 있으므로 외과, 영상 의학과, 방사선 종양학과, 병리학과, 내과 의사 간의 다학제 치료가 중요하다.

Gallbladder cancer is the most common of all the biliary tract cancers. Incidence gradually increases with age, and women are more likely diagnosed with gallbladder cancer. Patients with gallbladder cancer have poor prognosis due to early local and vascular invasion, extensive regional lymph node metastasis, and distant metastasis. Gallbladder cancer is also related with shorter median survival duration and shorter survival duration after recurrence in comparison with hilar cholangiocarcinoma. Complete removal with negative margins is considered as the only curative therapy for patients with gallbladder cancer. The optimal resection comprises cholecystectomy with a limited hepatic resection (segments IVB and V) and portal lymphadenectomy to include the tumor with negative margins. The optimum adjuvant therapy for patients with resected gallbladder cancer has not been confirmed. The greater benefit of radiation therapy was achieved in patients with T2 or greater stage tumors and nodepositive disease. Primary options for patients with unresectable or metastatic diseases include: 1) clinical trial; 2) fluoropyrimidine-based or gemcitabine-based chemotherapy; or 3) best supportive care including biliary drainage. In patients with advanced stage and jaundice, biliary drainage should be considered before setting up chemotherapy.

목차
서 론
 본 론
  1. 수술 중 발견된 담낭암
  2. 조직검사에서 진단된 우연히 발견된 담낭암
  3. 영상 검사에서 종물로 진단된 담낭암
  4. 황달로 진단된 담낭암
  5. 다학제 치료
 결 론
 요 약
 REFERENCES
저자
  • 박창환(전남대학교 의과대학 내과학교실, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea) | Chang-Hwan Park Corresponding author