Purpose: The purpose of this study was to examine the association of physical activity with self-efficacy and the internet addiction in adolescents. Methods: A total of 387 middle school students(1st and 2nd grade; 197 males) completed questionnaires to assess the internet addiction, self-efficacy, physical activity intention, and physical activity. The data analysis was conducted using t-test and multiple regression analysis with SPSS 20.0. Results: Results revealed that there was no significant difference in physical activity between the internet addicted group and non-addicted group, but physical activity intention was negatively correlated with the level of internet addiction and positively correlated with self-efficacy. Regression analysis showed that intention negatively predicted the internet addiction and self-efficacy moderated the effect of intention on the internet addiction. Conclusion: The results of the study suggest that physical activity may be helpful to improve problematic internet use in adolescents, and the strategy of enhancing physical activity intention and self-efficacy should be involved in an internet addiction prevention program for adolescents.