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중합체 매개 용융압출에 의한 참당귀 나노복합체의 제조

Fabrication of Nano-composite from Radix of Angelica gigas Nakai Mediated Polymer Matrixs by Hot Melt Extrusion

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  • URLhttps://db.koreascholar.com/Article/Detail/362869
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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : The objective of this study was to make colloidal dispersion of the active compound was characterized nano-composite from radix of Angelica gigas Nakai using hot melt extrusion (HME). Therefore, food grade hydrophilic polymer matrices was used to disperse compound in aqueous media.
Methods and Results : Extrudate solid formulations (ESFs) mediated various HPMCs (hydroxypropyl methylcellulose) and Na-Alg polymer from ultrafine powder of radix of Angelica gigas Nakai was developed through physical crosslink method (HME) with ionization agent (treatment of acetic acid) and food grade polymer [HPMCs such as HP55, CN40H, AN6 and sodium alignate (Na-Alg)]. X-ray powder diffraction (XRD) analysis confirmed the amorphization of crystal compounds in extrudate solid formulations mediated HP55 (HP55-ESF). Differential scanning calorimetry (DSC) analysis indicated a lower enthalpy (ΔH = 10.62 J/g) of glass transition temperature (Tg) in HP55-ESF. Infrared fourier transform spectroscopy (FT-IR) reveled new functional groups produced in HP55-ESF. Phenolic compound, flavonoid (including decursin and decursinol angelate) and antioxidant activity increased at 5, 10 and 2 times in HP55-ESF. Water solubility (61.5%) nano size (323 ㎚) particle was achieved in the HP55-ESF.
Conclusion : Nano-composites have been developed utilizing melt-extruded solid dispersions technology by food grade polymer enhanced nano dispersion (< 500 ㎚) of active compound from radix of Angelica gigas Nakai with enhanced solubility and bioavailability. This nano-composites of radix of Angelica gigas Nakai developmental and marketed products to enable therapeutic performance.

저자
  • 이한나(강원대학교 생약자원개발학과) | Hannah Lee
  • 김수진(강원대학교 생약자원개발학과) | Soo Jin Kim
  • Md Obyedul Kalam Azad(강원대학교 생명건강공학과)
  • 강위수(강원대학교 생명건강공학과) | Wie Soo Kan
  • 박철호(강원대학교 생명건강공학과) | Cheol Ho Park
  • 조현종(강원대학교 약학과) | Hyun Jong Cho
  • 임정대(강원대학교 생약자원개발학과) | Jung Dae Lim Corresponding author