The subfamily Mirinae is the most diverse group in Heteroptera, composed of at least 4,100 described species worldwide. This subfamily is also one of the most important groups in agriculture and in forestry, containing many well-known pests and predators which can be used as a biological control agent. However, the monophyly and generic relationships of each group within this subfamily have been unclear due to the lack of phylogenetic analysis. In this talk, the first comprehensive phylogenetic analyses of this subfamily are presented based on total evidence data. Major questions on the basis of the results are discussed, including the monophyly and relationships among the tribes and main genera, and the evolution of important characters in each group.