In this study, we evaluated the anti-cancer activity and potential molecular mechanism of 70% ethanol extracts of branches from Taxillus yadoriki parasitic to Neolitsea sericea (TN-NS-B) against human lung cancer cells, A549. TY-NS-B dose-dependently suppressed the growth of A549 cells. TY-NS-B decreased β-catenin protein level, but not mRNA level in A549 cells. The downregulation of β-catenin protein level by TY-NS-B was attenuated in the presence of MG132. Although TY-NS-B phosphorylated β-catenin protein, the inhibition of GSK3β by LiCl did not blocked the reduction of β-catenin by TY-NS-B. In addition, TY-NS-B decreased β-catenin protein in A549 cells transfected with Flag-tagged wild type β- catenin or Flag-tagged S33/S37/T41 mutant β-catenin construct. Our results suggested that TN-NS-B may downregulate β- catenin protein level independent on GSK3β-induced β-catenin phosphorylation. Based on these findings, TY-NS-B may be a potential candidate for the development of chemopreventive or therapeutic agents for human lung cancer.

Abstract
 서 언
 재료 및 방법
 결과 및 고찰
 적 요
 References

• 박수빈(국립안동대학교 생약자원학과) | Su Bin Park (Department of Medicinal Plant Resources, Andong National University)
• 김하나(국립안동대학교 생약자원학과) | Ha Na Kim (Department of Medicinal Plant Resources, Andong National University)
• 김정동(국립안동대학교 생약자원학과) | Jeong Dong Kim (Department of Medicinal Plant Resources, Andong National University)
• 박광훈(국립산림과학원 산림약용자원연구소) | Gwang Hun Park (Forest Medicinal Resources Research Center, National Institute of Forest Science)
• 어현지(국립산림과학원 산림약용자원연구소) | Hyun Ji Eo (Forest Medicinal Resources Research Center, National Institute of Forest Science)
• 안미연(국립안동대학교 생약자원학과) | Mi-Yun An (Department of Medicinal Plant Resources, Andong National University)
• 정진부(국립안동대학교 생약자원학과) | Jin Boo Jeong (Department of Medicinal Plant Resources, Andong National University) 교신저자