Revolutionary advancements, such as the reduction in DNA sequencing costs and genome editing, have transformed biotechnology, fostering progress in manipulating biomolecules, engineering cells, and computational biology. Agriculture and food production have significantly benefited from tools like high-throughput microarrays, accelerating the selection of desired traits. Genetic engineering, especially utilizing genome editing, facilitates precise alterations in plants and animals, harnessing microbiomes and fostering lab-grown meat production to alleviate environmental pressures. The emergence of new biotechnologies, notably genome editing, underscores the necessity for regulatory frameworks governing LM (living modified) organisms. Global regulations overseeing genetically engineered or genome-edited (GE) organisms, encompassing animals, exhibit considerable diversity. Nonetheless, prevailing international regulatory trends typically exclude genomeedited plants and animals, employing novel biotechnological techniques, from GMO/ LMO classification if they lack foreign genes and originate through natural mutations or traditional breeding programs. This comprehensive review scrutinizes ongoing risk and safety assessment cases, such as genome-edited beef cattle and fish in the USA and Japan. Furthermore, it investigates the limitations of existing regulations related to genome editing in Korea and evaluates newly proposed legislation, offering insights into the future trajectory of regulatory frameworks.

INTRODUCTION
NEW BIOTECHNOLOGY: GENOME EDITING
REGULATORY APPORACHES FOR GE
    North America
    South America
    Japan and China
    European Union and United Kingdom
RISK ASSESSMENT IN GE ANIMALS
CURRENT REGULATORY FRAMEWORK OF LMANIMAL IN KOREA
DISCUSSION
REFERENCES

• Dajeong Lim(Division of Animal and Dairy Sciences, College of Agriculture and Life Sciences, Chungnam National University, Daejeon 34134, Korea)
• Inchul Choi(Division of Animal and Dairy Sciences, College of Agriculture and Life Sciences, Chungnam National University, Daejeon 34134, Korea)