한국식품영양학회지 Vol. 30 No. 4 (p.735-741)

효모추출복합물과 헛개나무 열매추출 복합물이 알코올 대사에 미치는 영향무작위, 이중맹검, 위약 대조군, 교차 인체적용시험

Effects of Improving Alcohol Metabolism of Yeast Extract Mixtures and Hovenia dulcis
키워드 :
alcohol hangover,yeast extract mixtures,Hovenia dulcis mixtures,alcohol concentration,acetaldehyde concentration

초록

This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men.In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and Cmax for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and Cmax for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.