Hylotelephium erythrostictum is commonly used as a medicinal herb. In this study, H. erythrostictum leaf (HEL), branch (HEB), root (HER), and above ground (HEAG) extracts were evaluated for their antioxidant properties. The antioxidant activities were assayed by three methods based on scavenging of DPPH, ABTS and superoxide anion radical. HEAG extract showed the highest DPPH, ABTS, superoxide anion radical scavenging activities. HEAG extract also exhibited the highest phenolic content (230 mg/g gallic acid equivalent). In our research for anti-inflammatory ingredients, the extract of HEAG inhibited the generation of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. To test the inhibitory effects of HEAG on pro-inflammatory cytokines, we conducted ELISA assay for the measuring the generation of tumor necrosis factor (TNF)-α, IL (interleukin)-1β, and IL(interleukin)-6 in LPS-stimulated RAW264.7 macrophage cells. In these assays, HEAG ethanol extract showed a dose-dependent decrease in the production of TNF-α, IL-1β, and IL-6. Based on these results, extract of HEAG could be the efficient candidate for anti-inflammatory agents.

• 김상숙(국립원예특작과학원 감귤연구소) | Sang Suk Kim (Citrus Research Institute, National Institute of Horticultural and Herbal Science, RDA, Jeju 63607, Korea) Corresponding author
• 박경진(국립원예특작과학원 감귤연구소) | Kyung Jin Park (Citrus Research Institute, National Institute of Horticultural and Herbal Science, RDA, Jeju 63607, Korea)
• 이승은(국립원예특작과학원 인삼특작부) | Seung Eun Lee (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Korea)
• 이정훈(국립원예특작과학원 인삼특작부) | Jeong Hoon Lee (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Korea)
• 최영훈(국립원예특작과학원 감귤연구소) | Young Hun Choi (Citrus Research Institute, National Institute of Horticultural and Herbal Science, RDA, Jeju 63607, Korea)