한국자원식물학회지 Vol.30 No.6 (p.601-611)

Effects of the Jinan Red Ginseng Extract Treatment on Poloxamer 407-induced Hyperlipidemia in Rabbits

키워드 :
High-density lipoprotein,Hyperlipidemia,Red Ginseng

목차

Abstract
Introduction
Materials and Methods
  Experimental animals
  Induction of experimental hyperlipidemia - Procedure forinjecting poloxamer 407
  Red Ginseng treatment
  HPLC Analysis of Red Ginseng extract
  Biochemical analysis
  Statistical analysis
Results
Discussion
References

초록

Hyperlipidemia is an increase in one or more of the plasma lipids, including triglycerides, cholesterol. Ginseng has been used as a valuable tonic and for the treatment of various diseases. The objective of this study was to evaluate the effects of Jinan red ginseng (JRG) water extract on the blood and serum in rabbits with hyperlipidemia induced by poloxamer 407 when supplied in drinking water. JRG treatment was performed for 20 weeks. We evaluated the effects of the JRG treatment on diabetes through hematological and biochemical analysis before and after JRG treatment were performed. Our results indicate that LDL, total cholesterol, and triglycerides were significantly decreased compared prior JRG supply. CRE, BUN, CK and UA levels indicating renal functions are significantly reduced when compared to those prior to the JRG supply. In addition, AST, ALT, ALP, and LDH were significantly reduced indicating hepatoprotective effect. Blood electrolytes deteriorated in HL rabbits were improved when JRG supplied. In conclusion, Biochemical and hematological analysis demonstrate that the JRG is effective to alleviate the hyperlipidemia signs.