산업식품공학 제22권 제4호 (p.358-365)

고지방식이 동물모델에서 통곡물 시리얼의 근감소성 비만 예방 효과

Preventive Effects of Whole Grain Cereals on Sarcopenic Obesity in High-fat Diet-induced Obese Mice
키워드 :
whole grain cereal,sarcopenic obesity,anti-obesity,skeletal muscle mass,muscle strength

목차

Abstract
서 론
재료 및 방법
  식이 제조
  실험 동물 사육 및 식이
  미세단층촬영(Micro-computed tomography) 시스템을 이용한 체내 지방 및 근육 부피의 측정
  혈청 지질 지표 및 간기능 지표 분석
  조직학적 분석
  근력 측정
  통계 분석
결과 및 고찰
  WGC의 체중 및 식이효율 감소 효과
  WGC의 지방 무게 및 지방 세포 크기 감소 효과
  WGC의 비알콜성 지방간 및 혈중 지질함량 개선효과
  WGC의 근육 증강 효과
요 약
References

초록

Whole grain cereal (WGC)-rich diets provide macronutrients that are important for the regulation of energy metabolism. The current study evaluated whether WGCs had a preventive effect on sarcopenic obesity in high-fat diet (HFD)-induced obese mice. C57BL/6N mice were fed a normal diet (ND), ND+WGC, HFD, and HFD+WGC for 12 weeks. WGCs significantly reduced body weight gain, food efficiency ratio, fat mass, and adipocyte size in HFD-induced obese mice. WGCs attenuated HFD-induced nonalcoholic fatty liver disease by decreasing liver weight and hepatic fat accumulation. In addition, WGCs increased muscle strength and muscle mass in HFD-induced obese mice as well as in ND mice. Taken together, WGCs can be employed as functional food materials for the prevention of sarcopenic obesity by inhibiting fat accumulation and increasing muscle mass.