한국환경과학회지 제28권 제11호 (p.943-950)

|ORIGINAL ARTICLE|
Sodium Fluoride 함량이 흰쥐의 간 기능 효소활성에 미치는 영향

Influences of Sodium Fluoride Contents on Hepatic Functional Enzyme Activities in Rats
키워드 :
Sodium fluoride (NaF),Aminotransferase (AST,ALT),Alkaline phosphatase (ALP),Lactate dehydrogenase (LDH)

목차

Abstract
1. 서 론
2. 재료 및 방법
   2.1. 실험재료
   2.2. 실험 동물
   2.3. 식이조성 및 실험군
   2.4. 실험 동물의 처리
   2.5. 효소 활성의 측정
   2.6. 불소(F) 함량의 측정
   2.7. 통계 처리
3. 결과 및 고찰
   3.1. Alkaline phosphatase (ALP) 활성
   3.2. Aminotransferase (AST, ALT) 활성
   3.3. Lactate dehydrogenase (LDH) 활성
   3.4. 혈청 및 장기조직의 불소 함량
4. 결 론
REFERENCES

초록

The purpose of this study was to probe the influences of NaF oral administration on a dose-effect relationship between fluoride levels of serum enzyme activity such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in rats fed experimental diets for 5 weeks. All groups increased the activity of serum ALP, AST, ALT, and LDH levels with increasing NaF. In addition the fluoride levels of serum and organ tissues (liver, brain, heart, lung, kidney) in oral NaF groups (NF3~NF50) were significantly increased by adding sodium fluoride in comparison with normal diet group (ND) (p<0.05). These results, a high concentration of sodium fluoride was determined that the toxicity to various organ tissues.