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The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions KCI 등재

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한국자원식물학회지 (Korean journal of plant resources)
한국자원식물학회 (The Plant Resources Society Of Korea)
초록

Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor -κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.

목차
Introduction
Materials and Methods
    Reagents
    Animals
    Preparation of avocado extracts
    Scratching behavioral experiment
    Induction of AD-Like Skin Lesions and avocado treatment
    Evaluation of skin dermatitis severity
    Histamine assay
    Cytokine Assay
    Western blot analysis
    Caspase-1 activity
    Statistical analysis
Results
    Avocado suppress scratching behaviors in mice
    Avocado suppress AD symptoms in DNCB-induced AD-like skin lesions
    Avocado suppress IgE and histamine serum levels in DNCB-induced AD mice
    Avocado suppress the inflammatory cytokines expression in AD-like skin lesions
    Avocado suppress the NF-κB activation in AD-like skin lesion
    Avocado suppress caspase-1 activation in AD-like skin lesion
Discussion
References
저자
  • Noh-Yil Myung(Department of Oriental Medicine and Healthcare, Wonkwang Digital University)
  • Su-Jin Kim(Department of Biotechnology and Convergence, Daegu Haany University) Corresponding author