간행물
권호리스트/논문검색
제20권 1호 통권 33호 (2016년 6월) 62건
61.
2016.06
구독 인증기관·개인회원 무료
Ganoderma lucidum, a species of the class Basidiomycetes, attracts international attention due to the wide variety of its biological activities and great potential as cosmetic ingredient, such as skin care cosmetics including ‘skin-whitening’. However, there is little information available regarding the tyrosinase inhibitory activity. Therefore, the objectives of this study were to investigate the chemical composition and tyrosinase inhibitory activity of the G. lucidum. To isolate active single compound from G. lucidum (GASC), we conducted ethanol extraction and chloroform fractionation. In addition, we assayed the inhibitoty effect of tyrosinase activity and melanin biosynthesis in B16F10 mouse melanoma cells. In the present study, we identified a GASC, which exhibited inhibitory effects of cellular tyrosinase activity, the protein expression of cellular tyrosinase and tyrosinase-related protein-1, 2. In additional, microphthalmia-associated transcription factor (MITF), as known as crucial regulator of melanogenesis-related genes, was down-regulated by treatment with GASC in a concentration-dependent manner. GASC exhibited significant inhibition of tyrosinase activity and melanin synthesis in B16F10. The finding that melanogenesis inhibitory effect of GASC will contribute to facilitate various approaches of this mushroom for use in skin whitening products.
62.
2016.06
구독 인증기관·개인회원 무료
Cordyceps species are known to produce numerous active components and are used for diverse medicinal purposes because of their varied physiological activities, including their anticancer, anti-inflammatory, and antimicrobial effects. Cordycepin, one of adenosine analogues, differs from adenosine in that its ribose lacks an oxygen atom at the 3' position. Cordycepin has been reported to be a main effector molecule in Cordyceps extracts that executes antiviral activities against several viruses including influenza virus, plant viruses, human immunodeficiency virus (HIV), murine leukemia virus, and Epstein-Barr virus (EBV). In addition, adenosine and its deaminase inhibitor showed strong antiviral potentials that were about 4,000 times more potent than the activity of the direct inhibitory effect by adenine arabinoside on Herpes simplex virus (HSV)-1, suggesting adenosine itself plays an important role to produce antiviral activities. In this study, we show that cordycepin and adenosine possess antiviral and antitumor activities against EBV and EBVassociated gastric carcinoma, respectively. Furthermore, we report epigenetic mechanisms used by cordycepin and adenosine to exert their antiviral and antitumor effects.
