This study investigates the acute toxicity of sublethal tributyltin (TBT) exposure in the marine polychaetes Perinereis aibuhitensis by measuring changes in mortality, burrowing activity, acetylcholinesterase (AChE) function, and antioxidant defense mechanisms. The 96h-LC50 of TBT was established at 23.7 μg L⁻¹. Following exposure to 1 μg L⁻¹ of TBT led to a dose-dependent reduction in burrowing behavior and AChE activity in polychaetes. Elevated levels of malondialdehyde (MDA) and pronounced reduction of glutathione (GSH) contents explained significant oxidative stress. The major antioxidant enzymes, including GSH peroxidase, GSH reductase, catalase, and superoxide dismutase, were also significantly suppressed following TBT exposure. These findings indicate that TBT-induced acute toxicity compromises physiological functions and undermines antioxidant defense system in polychates.

해상에서의 안전한 의사소통은 선박 운항의 핵심 요소로, 국제해사기구(IMO)는 SMCP(Standard Marine Communication Phrases)를 제정하여 선내외 교신에서 활용할 수 있도록 하였다. SMCP를 포함한 해사영어는 효과적이고 정확한 의사소통을 위해 일반 영어와는 다 른 문법적, 어휘적, 구조적 특성을 반영하고 있으며, 간결성과 명확성에 초점이 맞추어져 표준화되어 있다. 이러한 맥락에서 본 연구는 상 용 LLM 모델의 해사영어 활용 능력을 PHP Text Similarity 알고리즘과 BERT 기반 모델을 활용하여 평가하였다. 먼저 ChatGPT, Google Gemini, Meta LLaMA 3 70B Instruct 모델을 대상으로 SMCP 기반 문장 구성, 용어 정의, 빈칸 채우기 문제를 포함한 총 60문항을 활용하여 성능을 비교 분석하였다. 이후 해사고등학교 학생들의 시험 결과와 LLM 모델의 결과를 비교하여, LLM이 실제 해기사 교육 수준과 비교 했을 때 어느 정도의 해사영어 이해 및 문장 구성 능력을 갖추었는지 평가하였다. 대체적으로 LLM 모델들은 높은 정답률을 보였으나, 표 준화된 문구를 정확하게 활용하거나 관용적으로 사용되는 해사영어 표현을 이해하고 적용하는 데 한계점이 있음을 확인하였다. 본 연구 는 해기교육기관 및 실무 현장에서 상용 LLM 모델의 해사영어 활용 가능성을 평가하는 기초 자료로 활용될 수 있을 것으로 기대되며, 향 후 보다 정교한 모델을 대상으로 추가연구가 필요하다.

This study aimed to analyze the characteristics of the New-Chinese style appearing in Chinese fashion designer Shiatzy Chen’s collections and, accordingly, recommend various directions for the New-Chinese style design. Regarding the research method, the background and concept of Chinese style and New-Chinese style were reviewed, while relevant characteristics were derived from prior research. Concerning the data collection, 21 season collections from A/W 2014 to A/W 2024, were selected, and 26 reviews and 1,168 collection data were collated. The results are as follows: First, “multicultural convergence” emerges as design methods reflecting social changes and utilizes diverse cultural elements. In fashion design, it emerges in a harmonious combination of culture and artistic styles, expressing the integration of varied cultures —for instance, East–West cultural convergence. Second, “historical tradition” consistently expresses Shiatzy Chen’s fashion; continuously explores Chinese people’s garments and aesthetics; and integrates oriental dignity, culture, and discipline into fashion design. Third, “temporary diversity” refers to a Chinese fashion design culture that represents the seamless blending of traditional culture and modern social values— leading the new consumer market by combining new and old generations, graffiti aesthetics on modern streets, and traditional and contemporary expressions. Fourth, “positive metaphor” expresses the intrinsic mental element and emphasizes covert rather than overt beauty. These expressions metaphorically communicate ancient Chinese legends via artistic techniques, such as contemporary illustration and embroidery, thereby conveying an active mental culture.

곤충 Laccifer lacca의 분비물인 stick lac에서 얻어지는 락색소는 물에 용해되는 붉은색 식용 색소로, 식품에 붉 은 색을 더하는 착색제이다. 주요 성분은 안트라퀴논계 기 반의 laccaic acid로 A, B, C, D, E로 구성된다. 본 연구 의 목적은 HPLC-DAD를 활용하여 laccaic acid를 정량적 으로 분석할 수 있는 방법을 검증하는 것과 섭취 노출량 을 산출하는 것이다. 제안된 분석법은 특이성, 선형성, LOD, LOQ, 정확성, 정확도 등 다양한 검증 항목에서 평 가되었으며, 매트릭스 효과 또한 충분히 고려되었다. 모든 매트릭스에서 검량선은 높은 선형성 (R20.999)을 보였고, 락색소의 MDL과 MQL은 각각 1.93 mg/kg와 5.86 mg/ kg로 확인되었다. 일내 및 일간 회수율 시험에서 정확도 는 91.5-100.9% 사이였고, 정밀도는 0.8-2.6%RSD로 AOAC 기준을 충족하였다. 한국에서 유통되는 다양한 식 품들을 수집하여 락색소를 모니터링하여 식품 유형별 락 색소 섭취 노출량을 평가하였다. 락색소 섭취 수준의 범 위는 국민전체, 섭취자 각각 0.0000-0.0027 mg/kg·bw/day 와 0.0000 -0.0306 mg/kg·bw/day였다. 개발된 분석법은 다 양한 식품 유형에 적용 가능하여 락색소 추출물의 효과적 인 모니터링을 가능하게 하며, 섭취량 평가를 통해 락색 소의 안전성 평가에 추가적으로 활용될 수 있을 것이다.

Background: With the increase of seated work, interest in forward head posture (FHP) has grown. Prolonged computer tasks with FHP have been considered a factor that increases the stiffness and tone of the upper trapezius (UT) muscle. Traditionally, many studies have measured the craniovertebral angle (CVA) in standing positions to assess FHP, making it difficult to determine whether the CVA measured in a habitual working posture correlates with the stiffness and tone of the UT muscle in office workers. Objects: This study aimed to investigate the relationship among CVA, UT muscle stiffness, and tone in both habitual working and standing postures among asymptomatic office workers. Methods: Forty asymptomatic office workers participated in the study. CVA was measured in both habitual working and standing postures. Stiffness and tone of the UT muscle were assessed after a 10-minute computer task. Pearson’s correlation coefficient was used to investigate the relationship between CVA and stiffness and tone of the UT muscle. Results: No significant correlations were found between CVA in standing posture and the stiffness and tone of the UT muscle. However, moderate negative correlations were observed between CVA measured in the habitual working posture and both the stiffness (dominant: r = –0.490, non-dominant r = –0.465) and tone (dominant: r = –0.501, non-dominant r = –0.446) of the UT muscle. Conclusion: This study highlights that decreased CVA in habitual working posture is associated with increased stiffness and tone of the UT muscle in asymptomatic office workers. Therefore, measuring CVA in the habitual working posture should be considered when evaluating stiffness and tone of the UT muscle.

Though Farnesiferol C (FC) derived from Ferula asafoetida is known to have antiangiogenic and apoptotic effect in gastric, breast, nonsmall lung cancers, the underlying antitumor mechanism of FC is not fully understood so far. Hence, in the current study, apoptotic mechanism of FC was explored in colon cancers in association with carbon catabolite repression 4-negative on TATA-less 2 (CNOT2)/c-Myc signaling. Herein FC significantly increased cytotoxicity and reduced the number of colonies in HCT116 cells more effectively than in SW480 cells, though FC enhanced sub-G1 cell population in HCT116 and SW480 cells compared to untreated control. Consistently, FC activated the cleavages of Poly ADP-ribose polymerase (PARP) and Bax and attenuated the expression of pro-PARP and Cyclin D1 in HCT116 cells better than SW480 cells. Also, FC significantly reduced the expression of CNOT2 and c-Myc. Also, FC reduced of c-Myc stability in HCT116 cells by cycloheximide assay. Notably, CNOT2 depletion reduced the expression of c-Myc, while c-Myc depletion also attenuated the expression of CNOT2 in HCT116 cells, implying the crosstalk between CNOT2 and c-Myc. Furthermore, overexpression of c-Myc or CNOT2 promoted the expression of pro-PARP in HCT116 cells. Overall, these findings suggest that FC induces apoptosis via inhibition of CNOT2 and c-Myc in colon cancers for a potent anticancer candidate for further agriculture cultivation in Korea.

Background: Ankle flexibility is important for maintaining proper biomechanical function. Static stretching is used to improve flexibility with minimal risk; however, its effects are often temporary. Transfer of energy capacitive and resistive (TECAR) therapy has the potential to enhance muscle flexibility and circulation through deep heat applications. However, comparative studies evaluating the effectiveness of TECAR therapy and static stretching are lacking. Objects: This study aimed to compare the effects of static stretching therapy (ST) and combined TECAR and static stretching therapy (T-ST) in subjects with gastrocnemius muscle (GCM) tightness. Methods: Twenty-seven participants with bilateral GCM tightness were enrolled. To administer the ST and T-ST, which were each applied to both legs, the participants stood for 15 minutes on a wedge with a 0°–15° incline, with both feet on the wedge during ST and with TECAR therapy in resistive energy transfer mode applied to only one side of the GCM during T-ST. Muscle stiffness (MyotonPRO), dorsiflexion range of motion (DF-ROM), peak torque, and pennation angle (PA) of the GCM were measured before and after the intervention. Normality was confirmed using the Shapiro–Wilk test. Differences between the ST and T-ST leg conditions and between pre- and post-intervention changes in the legs were analyzed using paired t-tests. Results: There were no significant differences in any of the measured variables between the legs before the intervention. ST and T-ST legs showed significant improvements in all measured variables after the intervention (p < 0.05). T-ST legs demonstrated a significantly greater increase in DF and a greater decrease in PA than ST legs (p < 0.05). Conclusion: T-ST outperformed ST in reducing PA and increasing DF-ROM by promoting deep tissue relaxation and stimulating metabolic activity. This may lead to reduced pain and greater flexibility compared to ST. Maintaining an optimal PA ensures efficient force transmission during exercise, as evidenced by the observed increase in peak torque.

Background: Chronic low back pain (CLBP) is associated with trunk and lower extremity muscle weakness. Kneeling squat (KS) is a hip-focused exercise commonly used in the activities of daily living. However, research on trunk and lower extremity muscle activity across movement phases (ascending, holding, and descending) during KS remains limited and warrants further investigation. Objects: To determine the muscle activity of transversus abdominis/internal oblique (TrA/IO), erector spinae, gluteus maximus (Gmax), gluteus medius (Gmed), rectus femoris (RF) in the contraction phases of KS in individuals with CLBP. Methods: Surface electromyography data were recorded during KS across the ascending, holding, and descending phases on the side with CLBP. A 60-bit metronome was used to control the exercise speed. Results: The muscle activity of the TrA/IO was significantly higher during the holding phase than during the ascending and descending phases. The Gmax and Gmed were significantly higher during the holding phase than during the descending phase, whereas, RF was significantly higher during the ascending phase than during the holding and descending phases. Conclusion: The holding phase of KS may be recommended as a trunk and lower extremity exercise to increase in TrA/IO, Gmax, and Gmed muscle activity. Additionally, the ascending phase activates RF muscle in individuals with CLBP.