Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.

This study investigates the microstructure and thermal shock properties of polycrystalline diamond compact (PDC) produced by the high-temperature, high-pressure (HPHT) process. The diamond used for the investigation features a 12~22 μm- and 8~16 μm-sized main particles, and 1~2 μm-sized filler particles. The filler particle ratio is adjusted up to 5~31% to produce a mixed particle, and then the tap density is measured. The measurement finds that as the filler particle ratio increases, the tap density value continuously increases, but at 23% or greater, it reduces by a small margin. The mixed particle described above undergoes an HPHT sintering process. Observation of PDC microstructures reveals that the filler particle ratio with high tap density value increases direct bonding among diamond particles, Co distribution becomes even, and the Co and W fraction also decreases. The produced PDC undergoes thermal shock tests with two temperature conditions of 820 and 830, and the results reveals that PDC with smaller filler particle ratio and low tap density value easily produces cracks, while PDC with high tap density value that contributes in increased direct bonding along with the higher diamond content results in improved thermal shock properties.

The purpose of this study was to define more precisely the anatomy of the thumb flexor pulley system and to determine the relative contribution of each of the pulleys to the biomechanics of thumb motion at the metacarpophalangeal (MP) and interphalangeal (IP) joints. For this, 22 hands from 11 cadavers were used and randomly assigned to two groups. In the first group, the first annular (A1) pulley was cut first followed by the variable annular (Av) pulley and then the oblique pulley. In the second group, the oblique pulley was cut first followed by the, pulley and then the Av pulley. In 7 of 22 hands, it was a transverse structure parallel to the, pulley with a gap between the A1 and Av pulleys, referred to here as type I. In 9 hands, the A1 and Av pulleys were connected without any gap (type II). In 6 hands, the space between the A1 and Av pulleys were triangular in shape with fibers of the Av pulley converging toward the radial side (type III). In biomechanical study of both first and second experiments, there was no significant difference in MCP joint flexion between the all intact, A1 section, A1/Av section, A2 intact (A1/Av/oblique section), and no pulley configuration (p>.05). In occurring displacements less than 10 mm, there was no significant difference in IP joint flexion (p>.05). However, there was a significant decrease in IP joint flexion occurred in both 15 mm and 20 mm excursion (p<.05), when the oblique pulley was resected additionally after cutting the A1 and Av pulleys in first experiment, and when the A1 pulley was resected additionally after cutting the oblique pulley. According to the results, the injury of only the oblique pulley does not decrease thumb motion significantly. The oblique pulley injury with both the A1 and Av pulleys laceration decreased thumb motion significantly. The additional laceration of the A2 pulley does not decrease thumb motion.

Arctic sea ice as an indicator of climate change plays an important role in controlling global climate system. Thus, accurate observation and prediction of Sea Ice Concentration (SIC) is essential for understanding global climate change. In this study, we aim to improve the prediction accuracy of SIC by using machine learning and Regional Climate Model (RCM) data for a more robust method and a higher spatial resolution. Using the CORDEX RCM and NASA SIC data between January 1981 and December 2015, we developed three statistical models using Multiple Linear Regression (MLR), Support Vector Machine (SVM), and Deep Neural Network (DNN) which can deal with the non-linearity problem, respectively. The DNN model showed the best performance among the three models with the significant correlation between the predictive and observed SIC (r=0.811, p-value < 0.01)and the Root Mean Square Error (RMSE) of 0.258. With deeper considerations of the polar fronts and the characteristics of ocean current and tide, the DNN model can be applied for near future prediction of Arctic sea ice changes.

국가 전략적 차원에서 전체 사회기반시설물에 대해 미래에 필요한 유지보수 예산 파악하는 것은 매우 중요한 부분이다. 그러나 현 재 국내에서는 전체 대규모 시설물에 적용할 수 있는 유지보수비용 예측 기법이 거의 전무한 실정이다. 본 연구에서는 현재 국내에서 가용한 자 료와 적용 가능한 예측모델을 토대로 우리나라 전체 향후 SOC 시설물에 대한 향후 유지보수 투자 규모를 예측하였다. 실제 지출비용과 비교하 여 가장 적합한 예측모델을 선정하고 관리주체에서 과거에 지출한 유지보수비용 자료를 이용하여 일부 모델은 개발하여 교량, 터널, 포장, 항 만, 댐, 공항, 상수도, 하천, 항만 등의 사회기반시설물에 대한 최적의 미래 유지보수 비용을 산출하였다. 앞으로 10년간 총 비용예측결과, 8종의 사회기반시설물에 대하여 약 23조원이 필요한 것으로 나타났으며, 가장 비용이 크게 발생하는 시설물은 도로포장, 도로교량으로 나타났다.

본 연구에서는 비용예측모델과 성능예측모델을 이용하여 네트워크 레벨에서 향후 교량과 터널 유지관리 비용과 성능을 예측할 수 있는 방법론은 개발하였다. 현재 국내의 시설물 유지관리 관련 연구는 대부분 단일 시설물에 집중되어 있어 도로망차원의 네트워크 레벨 분석 에는 적용하기 어렵다. 따라서 시설물군 단위로 유지관리 계획을 수립해야하는 실무주체에게 유의한 정보를 제공하지 못하고 있는 실정이다. 본 연구의 예측모델은 시설물의 성능에 현재 시특법에 의해 평가하고 있는 상태외 사용성과 기능성을 포함하였으며, 기본 분석과 확장 분석을 통해 각 시설물의 조치 시기와 연간 예산을 추정할 수 있다. 또한 사례 분석을 통해 기술적 타당성을 검증하였다. 본 연구의 방법론이 활성화된 다면 다수의 시설물의 비용대비 미래 성능을 파악할 수 있으며, 효과적인 중장기 예산 수립을 할 수 있을 것으로 판단된다.

본 논문은 토목 시설물의 유지관리 분야에서 BIM을 도입하기 위해 필요한 핵심 표준화 항목과 그 추진 방안을 제시한다. 이를 위해 시설물의 유지관리에 관한 가치사슬과 BIM의 기술적 특성을 분석하여 가치사슬 상에서 최초로 수행되는 손상정보의 기록 방식이 BIM의 정보운용 방식과 매우 유사함을 밝혔다. 또한 시설물 유지관리 가치사슬 단계별로 수행되는 업무에 부합되는 BIM 데이터를 생산하고 운영하기 위해 필요한 표준화 항목을 제시하였다. 제시된 표준화 항목은 시설물의 전 생애주기에서 공통으로 적용되는 표준과 시설물 유지관리 목적에 맞추어 특화된 표준화 항목으로 구분하였으며, 각 구분된 항목에 대하여 표준화 추진 시 중심 역할을 수행할 수 있는 기관을 법령에 근거하여 제시하였다.

In this study, the use survey of domestic and international weather information on coastal regions and the demand survey (e.g. general and in-depth surveys) for customer needs with coastal industries were carried out to design customized coastal weather contents. The general demand survey showed that most of the customers working in the coastal industries were interested in a short-term forecast, such as a general weather outlook (approximately 29% of the total respondents) and typhoon information (19%), and they preferred to be given the forecast information from new media such as the internet web-pages (36%) and mobile utilities (23%) rather than old media such as TV (16%) and radio (11%). In addition, only 31% of the total respondents were found to be satisfied with the use of the current coastal weather service. This low percentage might mainly be a result of lack of information accuracy (about 64%) and diversity (28%). From in-depth survey with site visiting, the need of coastal weather contents, such as weather elements, data form, a tool of communication, and forecast interval, differed with the working stages in three coastal industries (e.g. shipbuilding, maritime trade, and passenger transport industries).

For the purpose of evaluating the eco-efficiency(EE) on surplus heat generated from industrial process, techniques of life cycle assessment are adopted in this study. Because it can be indicated both environmental impacts and economic benefits, EE is well known as a useful tool for symbiosis network on the sustainable development of new projects and businesses. To evaluate environmental impacts, the categories were divided into two areas of resource depletion and global warming potential. It can be seen that environmental impact increased a little but much higher economic benefit on the company, environmental performance and economic value were improved on the apartment by the district heating, respectively. In result, eco-industrial park(EIP) project on surplus heat should be found sustainable new business because the EE was in the area of fully positively eco-efficiency and, moreover resource depletion was taken place than the reduction of greenhouse gas.

Eco-efficiency considers both environmental impacts and economic values. It is a useful tool for communicating with stakeholders for business decision making. This study evaluated the eco-efficiency factor (EEF) for the energy network of a dyeing company that supplies surplus heat to a neighboring apartment during the night. This symbiosis network is one of the eco-industrial park (EIP) projects in Korea and aims to benefit local residents and the industrial complex by utilizing surplus heat. In this study, two categories were annualized. The first quantified environmental burden based on CO2 emissions and quantified product value in terms of steam sales. The second used a variety of environmental factors, such as fossil fuel, water and waste, to quantify environmental burden and used steam sales to quantify value. The EEF of the symbiosis network was 1.6, using the global warming impact, and determined using the multiple variable, was 1.33. This study shows that the EEF depends on variable details of environmental burden but the values of this project were very high contrast to other business or EIP project.