Geosynthetics have been widely applied in waste landfill site for reinforcement, filtration, drainage, protection, and separation. Geosynthetics inevitably contact soil particle directly, composing a geosynthetic-soil interface corresponding to external conditions. In this study, particularly, the effects of chemical aggressors on the geosynthetic-soil interface were investigated under cyclic shear loading, based on the experimental approach. The Multi-purpose Interface Apparatus (M-PIA) was newly manufactured and modified for better performance. The Disturbed State Concept (DSC) and disturbance function were introduced and employed to estimate shear stress degradation based on the experimental study, quantitatively. New disturbance functions and parameters were mathematically evaluated. Microscopic observation by Focused Ion Beam (FIB) was utilized to clarify the reason of the variation of interface damage subjected to the chemical conditions. As a result, the variation of the cyclic shear behavior at the geosynthetic-soil interface was due to the different damage patterns of the soil particle surface. Furthermore, the numerical back-prediction based on the DSC parametric study of the cyclic shear stress-strain behavior was performed and verified the accuracy and applicability of the DSC parameters. Consequently, a general methodology to estimate the cyclic shear stress degradation of geosynthetic-soil interface considering chemical effects has been established and verified.