Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as oxiniacic acid in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.

Drug delivery system(DDS) have been actively studied for the past twenty years. Dual action agents are unique chemical entities comprised of two different types of antibacterial compounds covalently linked together in a single molecule in such a way that both components are able to exert their bactericidal properties. In spite of the advent of the antibacterial agent the sulfa agents are the most widely used antibacterial agent today. In this study, new antibacterials derivative was synthesized using glutaraldehyde such as crosslinking agent for the purpose of dual-action as DDS study. Antibacterial activity of these new synthetic derivative between their structures and activities were examined by disc diffusion method. As a result, new synthetic derivative exhibited the broad antibacterial activities against Gram(+) and Gram(-) bacilli. Especially, the antibacterial effect of new synthetic derivative against Gram negative(Esherichia. coli) was much stronger than that against Gram positive.

목분 충진제의 함량을 달리 하여 PE수지를 매트릭스로 하여 Wood Plastic Composites (WPC)를 제조하였다. 또한 매트릭스와 충진제간의 결합력을 증가시키기 위하여 커플링제를 사용하였으며, 보강재의 보강률과 커플링제 처리가 복합재의 기계적 물성에 미치는 영향과 계면현상을 관찰하였다. 커플링제로 MA를 사용하였을 경우에 tensile strength는 3wt%의 농도에서 25.91MPa의 최대값을 나타내었으며. MAOMS커플링제의 경우, 3wt%의 처리 농도에서 22.48MPa로 MA로 처리한 것보다 낮았다. 충격강도는 MA의 경우에는 3wt%일 때 44.38J/m의 최대값을 나타냈으며, MAOMS의 처리에서는 36.09J/m로 MA처리한 것보다 낮게 나타났다.

SMC(Sheet molding compound)욕조 생산시 발생하는 폐 FRP를 보강재로서 재활용하기 위하여 불포화 폴리에스테르 매트릭스 수지에 보강하고 보강재와 매트릭스 수지의 계면 결합력을 증진시키기 위하여 보강재를 실란계 커플링제[3-methylacryloxyviny1 silane (MAOS)]로 전 처리하여 복합재를 제조하고 기계적 물성 및 계면현사에 대하여 관찰하였다. 보강률이 20wt%인 복합재의 굴곡강도 및 굴곡탄성률이 각 각 110MPa, 8.0GPa로 가장 우수하였으며 커플링제(MAOS)의 노동가 0.50wt%인 복합재의 굴곡강도 및 굴곡탄성률은 약 10%정도 향상되어 각 각 120MPa, 9.2GPa을 나타내었다. 또한 주사전자현미경 관찰 결과 보강재를 커플링제(MAOS)로 처리한 복합재의 보강재와 매트릭스 수지는 물리, 화학적을 잘 결합하여 보강재와 매트릭스 수지의 계면에서 pull out현상이 확인되지 않았으며 크랙도 발생하지 않았다.

An experiment was carried out to determine effect of cultivar, drying agent concentration and preservative on the moisture content, temperature and quality changes of fall harvested oat(Avena sativa L.) hay during field curing and storage. The main plots

Many alternatives to Trichlorothane & Trichlorotrifluoroethane mainly used as cleaning solvent for industrial parts are developed and commercialized because the solvent is scheduled to phaseout after 1996. Considering there are many kinds of parts and contaminants in all parts cleaning, It is essential to investigating the characteristics and performance of the alternatives prior to use. For the contaminant of a standard oil, waters, hydrocarbon and halogen parts which are the comercially available and promising alternatives were experimented at the same condition of Trichlorothane & Trichlorotrifluoroethane to check the cleaning performance. Overally, the removal efficiency of halogen solvent parts was better than that of hydrocarbon or waters parts for removing the standard oil used in this experiment.

EMA-co-DAMA were synthesized from 2-diethylaminoethyl metacrylate and ethylhexyl metacrylate in acrylmonomer. To facilitate water emulsification, acrylic copolymer was cationized by acetic acid to produce acetated acrylic copolymer. The structures of the synthesized copolymer and acetated copolymers were confirmed by IR, NMR, and molecular weight was measure by GPC, and C.H.N elemental analysis. Acetated acrylic copolymers were perfectly emulsified in water and showed increased emulsion stability. Polymer dispersion for cement modifier[(PDCM-PED) water proof agent of cement for concrete in building construction] was prepared by blending of the guaternized acrylic copolymer syndisized above, sodium silicate, sodium gluconate and oleic acid emulsion. The result with prepared polymer dispersion of cement modifier was examined, and it was found that excellent waterprooffing effect ; Water permeability ratio is 0.50 under the water pressure of 100g/cm2 and 0.60 under 3kg/cm2, and water absorption ratio is 0.42~0.50 and 1.0~1.02 compressive strength ratio at mixed of water/PDCM-PED is 50 times.

The antibacterial and antifungal effect of grapefruit seed extract(GFSE) was investigated for its purpose of application to a diverse spectrum of field as sanitizers, disinfectants and preservatives. GFSE showed comparatively high content of such flavoniods as naringin and hesperidin and ascorbic acid. GFSE containing a low level of organic acids is a heavy viscous and water-soluble liquid. As a result of the antimicrobial test of GFSE, Bacillus subtilis and Aspergillus oryzae did not survive at detectable levels when treated with more than 100 ppm of GFSE. The minimum inhibitory concentrations of GFSE for a wide variety of pathogenic and putrefactive bacteria, fungi and yeasts were 100 ppm and 250 ppm, respectively. In the comparable electron micrograph of microbial cells treated with GFSE or not, we could conclude that GFSE destroy microorganisms by disrupting the functions of the cell wall membrane and microbial spores.

For the purpose of producing emulsified fire proofing agent for synthetic fibers, 2,3-dibromopropylmonoamido orthophosphate[DP-AOP] and bis(2,3-dibromopropyl)monoamidoorthophosphate[(DP)2AOP] were synthesized, and their structures were identified by instrumental analysis, respectively. Using three kinds of emulsifiers, O/W emulsified fire proofing agents, DPF and DPDPF, were obtained corresponding to DP-AOP and (DP)2-AOP, respectively. Various synthetic textiles were fire-retardant treated by prepared DPF and DPDPF, and fire retardancy and tearing strength of the resulting products were tested. The results showed that as the concentration of fire proofing agents increased, fire retardancy increased, but the tearing strength much decreased, where the tendencies of DPDPF were deeper than those of DPF. But, since the fire retardancy appeared favorable in the range of 10~20wt% of DPDPF, DPDPF is proven to be a fire proofing agent useful for various synthetic textiles.

A series of four sodium α-sulfo fatty vinyl ester oligomers including sodium α-sulfo lauric acid vinyl ester oligomer, sodium α-sulfo myristic acid vinyl ester oligomer, sodium α-sulfo palmitic acid vinyl ester oligomer and sodium α-sulfo stearic acid vinyl ester oligomer were examined for surface activities such as surface tension, foaming power, foam stability, emulsifying power, dispersion effect, solubilization of orange OT. The critical micelle concentration(CMC) was also evaluated. Consequently, these sodium α-sulfo fatty acid vinyl ester oligomers were shown to have a good cohesive power and dispersion effect.

Four fatty acid vinyl esters were synthesized by transesterification between vinyl acetate and lauric acid, myristic acid, palmitic acid, stearic acid, respectively. Fatty acid vinyl ester oligomers were prepared from polymerization of four fatty acid vinyl esters in the presence of potassium persulfate in methanol. The α-sulfonation of these four fatty acid vinyl ester oligomer were carried by direct addition of sulfur trioxide. Especially, molecular weights of sodium α-sulfo fatty acid vinyl ester oligomers were measured by boiling point method.

본 시험은 점착물질을 이용하여 솔잎혹파리 우화성충의 밀도를 감소시키기 위해 지면산포, 지피식생 및 수간산포의 세 방법으로 이 시험을 위해 조제한 점착제 를 이용하여 경기도 안양시 산본리에서 시기별로 시험한 결과는 다음과 같다. 1. 점착제로 선정된 의 조성은 피마자유 , Damar 수지 , Carnauba Wax 였으며 점성, 점도의 지속성이 우수하였고, 약해가 비교적 낮았다. 2. 지면산포구에서 우화최성기의 성충포획수는 대조구에 비해 G-II구는 가 감소 되었다. 3. 지피식생산포구에서는 우화최성기의 성충포획 수는 대조구에 비하여 P-I구는 , P-II구는 약 가 감소되었다. 4. 수간산포구에서는 충영형성율이 F-I구가 F-II구는 , F-II구는 로 처리시기가 빠를수록 충영형성율이 낮았으나 F-I구는 F-II구간에는 유의차가 없었으며 소나무의 상중하부위별 충영형성율은 유의차가 없었다. 5. 점착제의 산포시기는 전처리구에서 우화최성일 1주일전이 효과적이었다.

To develop eco-friendly microbial inoculants, siderophore-producing bacteria were isolated and identified, and their production characteristics and plant growth-promoting abilities were investigated. A strain S21 was isolated from rhizosphere of Korean perilla (Perilla frutescens) and identified as Enterobacter amnigenus by phenotypic properties and 16S rRNA gene sequencing. The highest siderophore production was obtained in a medium containing 0.5% fructose, 0.1% urea, 0.5% K2HPO4 and 0.1% succinic acid. By using this improved medium, siderophore production increased by 2.5 times compared to that of basal medium. The strain S21 showed insoluble phosphate solubilizing, ammonification and antifungal activities, and also produced hydrolytic enzymes (protease and lipase), indoleacetic acid and 1-aminocyclopropane-1-carboxylate deaminase. Our data suggest that E. amnigenus S21 is a potential candidate that can be used as eco-friendly biocontrol agent and biofertilizer.

라텍스 개질 콘크리트의 건축구조물 옥상 포장에 적용할 수 있는 기초연구로서, 포장면의 균열 저감을 위해 수축저감제의 혼입에 따른 모르타르의길이변화 성능을 평가하였다. 평가결과, 수축저감제를 혼입하지 않은 Plain에 비하여 수축저감제 혼입에 따라 모르타르 공시체의 길이변화율이 감소되는 것으로 나타났으며, 수축저감제 혼입량에 따른 변화량의 차이는 미소하였지만 균열저감 효과는 있는 것으로 확인되었다.

콘크리트는 외부로부터 침투하는 열화 인자들의 침투에 의해 철근이 부식하고 구조재료로써의 성능이 저하된다. 발수제를 직접 도포하거나 혼입하는 방법이 연구되고 있고, 본 연구에서는 발수제의 뭉침 및 떠오름을 방지하기 위하여 다공성 재료인 제올라이트를 혼입한 발수콘크리트 개발을 위한 기초연구를 수행하였다. 제올라이트 치환율에 따른 시험체를 제작하였으며, 접촉각 측정결과 치환량과 접촉각의 크기는 비례하여 증가하는 것을 확인하였다.