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        검색결과 11,815

        61.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        곧 다가올 미래에는 자율운항선박, 육상 원격제어센터에서 제어되는 선박, 그리고 항해사가 탑승하여 운항하는 선박이 함 께 공존하며 해상을 운항할 것이며, 이러한 상황이 도래했을 때 해상 교통 환경의 안전을 평가할 수 있는 방법이 필요할 것으로 사료 된다. 이에 본 연구에서는 자율운항기술을 사용하여 항해사가 직접 조종하는 선박과 자율운항선박이 공존하는 해상환경 하에서 선박 조종시뮬레이션을 통해 통항 안전성을 평가하기 위한 방안을 제시하였다. 자선은 6-자유도 운동 기반의 MMG 모델을 심층 강화학습 기법 중 하나인 PPO 알고리즘으로 학습하여 자율운항 기능을 갖출 수 있도록 설계하였다. 타선은 평가 대상 해역의 해상 교통 모델 링 자료로부터 선박이 생성되도록 하였고, 기 학습된 선박모델을 기반으로 자율운항 기능을 구현되도록 하였다. 그리고 해양기상 자 료 데이터베이스로부터 조위, 파랑, 조류, 바람에 대한 자료를 수집하여 수치 모델을 수립하고 이를 기반으로 해양기상 모델을 생성하 여 시뮬레이터 상에서 해양 기상이 재현되도록 설계하였다. 마지막으로 안전성 평가는 기존의 평가 방법을 그대로 유지하되, 선박조 종시뮬레이션에서 해상교통류 시뮬레이션을 통한 충돌 위험성 평가가 가능하도록 하는 시스템을 제안하였다.
        4,000원
        62.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구는 유색과 백색품종 토종오리의 성별에 따른 생산능력과 도체특성을 평가하고자 실시하였다. 1일령 토종오리 총 480수를 2개 품종(유색과 백색)×2개 성별(암컷과 수컷)로 총 4처리구의 4반복으로 반복 당 30수씩 평사에 나누어 8주간 사양실험을 진행하였다. 본 연구결과, 전체 사양실험기 간에서 토종오리의 체중, 증체량 및 사료섭취량은 품종(유색과 백색) 간 차이는 없었으나 수컷이 암컷보다 유의적으로 높았다(p<0.05). 이와 유사하게, 사료요구율은 유색품종과 백색품종의 차이가 없었으나 수컷이 암컷에 비해 유의적으로 개선됨을 확인하였다(p<0.05). 토종오리의 머리, 가슴육, 다리육 및 간의 무게는 처리구간 통계적 차이를 나타내지 않았다. 도체중량은 처리구간 차이가 없었으나, 도체율은 백색품종이 유색품종과 비교해 현저히 높았다(p<0.05). 또한 복강지방 무게는 수컷이 암컷에 비해 높았으며(p<0.05) 백색품종이 유색품종보다 높았다(p<0.05). 폐사율은 토종오리 의 품종과 성별에 따른 유의적 차이가 없었다. 본 연구결과는 토종오리의 육성기 단계에서 사육성적에 대한 기초자료로 이용될 것으로 사료된다.
        4,000원
        63.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        PURPOSES : Sprinkler facilities play a crucial role in extinguishing fires in the early stages of a building blaze. Data indicate that more than 96% of fires are suppressed by sprinklers before growing out of control. However, corrosion and pitting of the sprinkler piping can reduce system performance as facilities age. The purpose of this study is to develop an eco-friendly water-soluble corrosion inhibitor to improve the reliability and longevity of sprinkler piping. METHODS : This study compared and analyzed silicate-based sprinkler piping shrinkage agents as corrosion inhibitor against existing commercial options. Tests were conducted to evaluate reactivity with fire extinguishing water, including electrolyzed reduced water and normal water. The anticorrosive performance of the silicate-based corrosion inhibitor was evaluated under various conditions to establish suitability before potential development or commercialization. RESULTS : The new corrosion inhibitor demonstrated eco-friendly performance. In testing, none of the primary four hazardous substances that pose the most risk of harm to the human body (specifically, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg)) were detected. The inhibitor effectively reduced corrosion of carbon steel (SPP), with weight loss rates averaging 0.12% and not exceeding 0.27%. For copper (CDA 110) weight loss rates were up to 0.03%. Testing under constant temperature and humidity conditions show that the inhibitor kept weight loss was below 0.002 g, with no significant numerical value for the weight loss rate. Overall, the results indicate the potential for an environmentally-safe corrosion inhibitor. CONCLUSIONS : The optimal silicate-based sprinkler system can provide real-time sensor information such as oxygen saturation, pH concentration, and total dissolved solids (TDS). These metrics are closely related to the aging process. By linking this system with an aging monitoring solution, maintenance costs and safety could be improved over the lifespan of the sprinkler system. The sensors and monitoring capabilities are expected to enhance maintenance efficiency and equipment reliability.
        4,000원
        64.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구에서는 보육시설 내 식수인원 및 조리 종사자 근무현황에 따른 급식소 위생 관리수준을 평가하였다. 2021 년부터 2022년까지 풀무원푸드머스를 통해 식자재를 공급 받는 전국 199개 보육시설을 대상으로 61개 점검문항 중 평가결과에서 유의미한 일부 분석결과를 바탕으로 작성하 였다. 분석결과 식수인원이 적고, 조리 종사자가 적을수록 검수기록이 미 실시(P<0.05)되는 평가되었으며, 식수인원 이 적을수록 조리 종사자의 건강상태 확인이 미흡하고, 조 리 종사자가 적을수록 복장착용(P<0.05)이 미흡하였다. 또 한, 식수인원이 적은 보육시설일수록 소비기한 경과 식재 료 보관이 확인(P<0.05)되는 빈도 수가 높아 관리가 요구 되었으며, 가열조리 시 심부온도 측정기록은 미 실시(P<0.05) 되는 것으로 확인되었다. 그리고 식수인원이 적은 보육시 설일수록 조리시설의 유지관리가 미흡(P<0.05)하였다. ATP 측정결과에서는 식수인원이 적은 조리시설 종사자의 손과 도마에서 유의적으로 높은 ATP 수치가 검출(P<0.05)되었으 며, 조리종사자가 적을수록 근무 급식소의 도마에서 높은 ATP 수치(P<0.05)가 측정되었다. 분석결과를 종합해 볼 때 식수인원이 적은 보육시설일수록 조리운영을 위한 시설기반 관리가 부족하고, 위생관리가 미흡한 것으로 확인되었다. 따 라서 본 연구결과를 통해 식수인원 및 조리 종사자 수에 따 른 보육시설 급식소의 위생 관리수준을 판단하였으며, 향후 보육시설에 대한 국가 지원사업 선정 시 해당 연구결과가 기초자료로써 활용될 수 있을 것으로 사료된다.
        4,000원
        65.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구는 패류양식업이 밀집한 남해 강진만 해역에서 수하식 및 살포식 양식해역과 비양식해역을 구분하여 양식활동으로 인한 유기물 축적과 저서다모류군집 변화를 파악하고, 어장환경평가 기법을 활용하여 건강도를 평가하고자 수행되었다. 남해 강진만 해역의 평균 입도, 수온, 염분농도, 총유기탄소 등의 시·공간 분포는 정점간에 큰 차이가 없었던 반면, 출현 종수, 개체밀도와 종다양도 등은 살포식 양식 해역의 정점이 다른 해역의 정점과 비교해 상대적으로 낮은 경향을 보였다. 한편 집괴분석과 주요좌표분석 결과에서도 살포식 양식해역 정 점의 저서다모류군집이 나머지 정점의 군집과 뚜렷하게 구분되었다. 수하식 양식해역의 정점과 비양식해역 정점에서는 오염지시종인 Scolectoma longifolia와 Sigambra tentaculata가 우점종으로 출현하였으나, 수심과 해수 유통 등의 물리적인 요인에 의한 영향을 받는 일부 정점 을 제외하면 점유율이 높지 않았다. 강진만 해역의 저서생태계 건강도는 1~2등급으로 양호한 상태였다. 그러나, 다모류군집구조의 시·공간 분 포와 저서생태계 건강도지수를 고려하면 살포식 양식해역의 퇴적환경은 양식으로 인한 물리적인 교란에 영향을 받는 것으로 보여진다.
        4,300원
        66.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        A checklist of dietary behavior items for the elderly was developed based on Korean dietary guidelines. First, a literature review was conducted, and 63 preliminary items, including 30 items on food intake, 12 on eating habits, and 21 on dietary culture, were obtained to evaluate the dietary guidelines. The preliminary items were evaluated by experts using Lawshe’s method to verify the content validity. They were then revised, resulting in 52 items: 25, 11, and 16 in the food intake, eating habits, and dietary culture domains, respectively. A face-to-face survey was conducted on 331 people over 65 years of age in the metropolitan area, and their one-day food intake was surveyed using a 24-hour recall method in August 2022. The 48 items, including 24, 11, and 13 items on food intake, eating habits, and dietary culture, respectively, correlated significantly with the evaluation indicators of nutrient intake, such as mean adequacy ratio, dietary diversity score, and nutrient intake density. These items were considered suitable for evaluating the elderly's compliance with dietary guidelines.
        5,100원
        67.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구에서는 수소 자원의 활용도가 높아짐에 따라 수소 저장 용기의 내진 성능을 평가하기 위해 수소 저장 시설을 방문하여 현장 조사를 수행하였다. 외관 조사 중, 수조 저장 용기의 지지부에서 부식이 진행됨을 확인하였고, 이에 대한 대책안 으로 내부식성 재료인 CFRP로 대체하여 성능을 평가, 검증하였다. 이를 위해 현장 조사 결과를 바탕으로 상용 유한요소해석 프 로그램인 ABAQUS를 사용하였으며, 해석 결과 CFRP로 제작된 수소 저장 용기의 지지부는 강재 대비 약 12배 이상 뛰어난 성 능을 보였다. Hashin Damage Criteria를 기반으로 CFRP 지지부의 안전성 검토를 수행한 결과 최대 손상 지수가 0.065로 확인되 었다. 기초부 콘크리트의 경우, 쪼갬 및 휨 인장 응력에 대한 안전성을 검토하였으며, 허용 강도 대비 7~36%의 안전도를 보였 다. 이를 근거로 CFRP를 수소 저장 용기의 지지부에 적용하는 것은 합리적이며, 뛰어난 경제성을 보인다. 다만, 이러한 결과는 수치 해석에 의하므로 실규모 지진동 모사 시험을 통해 해석 모델의 신뢰성을 보충할 필요가 있다.
        4,000원
        68.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        PURPOSES : This study aimed to develop high-performance concrete repair materials for the cross-sectional repair of deteriorated bridge concrete. METHODS : To derive the optimal mix using the dry shotcrete method, experiments were conducted to develop an appropriate performance in terms of durability and watertightness based on basic experiments on materials. By mixing silica fume, GGBFS, and natural fibers, this study compared the differences in each variable. Each variable was compared using compressive strength, flexural strength, plastic shrinkage, chlorine ion penetration resistance, and freeze-thaw tests. RESULTS : By mixing silica fume and natural fibers, watertightness and durability were secured, and by adding an expansion material and polymer powder, a material that exhibited suitable performance as a repair material was developed. The material demonstrated suitable performance in terms of compressive strength, freeze–thaw resistance, plastic shrinkage crack resistance, and chlorine ion penetration resistance. CONCLUSIONS : The repair material developed in this study has a higher performance than repair mortar, and because it uses a dry shotcrete method, the process and post-processing are simpler than the wet shotcrete method; therefore, it is believed to be more efficient for repair work.
        4,000원
        69.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Occurrence of process environment changes, such as influent load variances and process condition changes, can reduce treatment efficiency, increasing effluent water quality. In order to prevent exceeding effluent standards, it is necessary to manage effluent water quality based on process operation data including influent and process condition before exceeding occur. Accordingly, the development of the effluent water quality prediction system and the application of technology to wastewater treatment processes are getting attention. Therefore, in this study, through the multi-channel measuring instruments in the bio-reactor and smart multi-item water quality sensors (location in bio-reactor influent/effluent) were installed in The Seonam water recycling center #2 treatment plant series 3, it was collected water quality data centering around COD, T-N. Using the collected data, the artificial intelligence-based effluent quality prediction model was developed, and relative errors were compared with effluent TMS measurement data. Through relative error comparison, the applicability of the artificial intelligence-based effluent water quality prediction model in wastewater treatment process was reviewed.
        4,800원
        70.
        2024.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        In response to the global trend of making sustainable development an urgent task, luxury fashion brands actively embrace it in their corporate philosophies and management policies. However, despite the widespread consensus in the related industry and the strong will of companies for the sustainable development of luxury brands, there are still few cases of luxury fashion brands successfully implementing sustainable development. This study examined the impact of the types of message framing on the sustainability marketing of luxury fashion brands, focusing on their effects on perceived message effectiveness, sustainable brand image, and brand attitudes. An online survey was administered to 464 Korean consumers in their 20s to 40s to test the hypotheses. The results showed that perceived effectiveness was higher for negatively framed messages (loss) than for their positive counterparts (gain). The types of message framing did not significantly affect sustainable brand messages, and no significant difference in perceived brand image was found, regardless of message type. Perceived message effectiveness exerted a significant positive effect on sustainable brand image, and such an image had a significant positive effect on brand attitudes. The results provide implications for related research and practical implications for the development of competitive sustainability marketing strategies for luxury fashion—an industry still in its infancy.
        4,900원
        71.
        2024.01 KCI 등재 SCOPUS 구독 인증기관 무료, 개인회원 유료
        High-Manganese (Mn) austenitic steel, with over 24 wt% Mn content, offers outstanding mechanical properties in cryogenic settings, making it a potential replacement for existing cryogenic materials. This high manganese steel exhibits high strength, ductility, and wear resistance, making it promising for applications like LNG tanks, flanges, and valves. To operate in cryogenic environments, hot forging and heat treatment processes are vital, especially in flange production. The cooling rate during high-temperature cooling after hot forging plays a critical role in influencing the microstructure and mechanical properties of high manganese steel. The rate at which cooling occurs during this process influences the size of the grains and the distribution of manganese and consequently has an impact on mechanical properties. This study assessed the microstructure and mechanical properties based on different cooling rates during the hot forging of High-Mn steel flanges. Comparing air and water cooling after hot forging, followed by heat treatment, revealed notable differences in grain size. These differences directly impacted mechanical properties such as tensile strength, hardness, and Charpy impact property. Understanding these effects is crucial for optimizing the performance and reliability of High-Mn steel in cryogenic applications.
        4,200원
        72.
        2024.01 KCI 등재 구독 인증기관 무료, 개인회원 유료
        In the case of the Pohang earthquake, which had a magnitude of 5.4 in 2017, geotechnical damages such as liquefaction and ground settlement occurred. The need for countermeasures has emerged, and experimental research in the Pohang area has continued. This study collected undisturbed samples from damaged fine-grained soil areas where ground settlement occurred in Pohang. Cyclic tri-axial tests for identifying the dynamic characteristics of soils were performed on the undisturbed samples, and the results were analyzed to determine the cause of ground settlement. As a result of the study, it was determined that in the case of fine-grained soils, ground settlement occurred because the seismic load as an external force was relatively more significant than the shear resistance of the very soft fine-grained soils, rather than due to an increase in excess pore water pressure.
        4,000원
        73.
        2024.01 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This paper describes the seismic performance evaluation of reinforced concrete bridge columns under constant and varying axial forces. For this purpose, nine identical circular reinforced concrete columns were designed seismically by KIBSE (2021) and KCI (2021). A comparison of lateral forces with theoretical strength shows that the safety factor for columns under varying axial forces is less marginal than those under constant axial forces. In addition, columns under varying axial forces exhibit significant fluctuations in the hysteretic response due to continuously varying axial forces. This is particularly prominent when many varying axial force cycles within a specific lateral loading cycle increase. Moreover, the displacement ductility of columns under varying axial forces does not meet the code-specified required ductility in the range of varying axial forces. All varying axial forces affect columns' strength, stiffness, and displacement ductility. Therefore, axial force variation needs to be considered in the lateral strength evaluation of reinforced concrete bridge columns.
        4,000원
        74.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        In this study, we investigated the change in fracture properties after friction stir welding on Al606. In the L-T direction test, the fracture toughness of the unwelded base material was 275 MPa, and the specimen subjected to friction stir welding (FSW) was 227 MPa, showing that the fracture toughness decreased significantly with friction stir welding. In the T-L direction test, the difference between the base material and the weld material was not large, but the fracture toughness was shown to decrease during welding. In the comparison of the L-T direction and the T-L direction, it was found that both the base material and the weld material showed high fracture toughness in the L-T direction.In this study, the following conclusions were obtained after friction stir welding of Al 6061-T6.
        4,000원
        75.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        집약적이고 장기적인 양식어업 활동은 많은 양의 유기물을 발생시켜 퇴적환경과 생태계를 악화시켜왔다. 정부에서는 양식어장 의 환경 보전과 관리를 위해서 어장관리법을 제정하였고 이를 근거로 2014년부터 어류 가두리 양식장에 대한 어장환경평가가 실시되었 다. 따라서 어장환경평가를 위해 국내 환경에 적합한 과학적이고 객관적인 평가방법의 개발이 필요하였다. 이를 위해 저서다모류 군집과 양식장의 주 오염원인 유기물의 관계를 이용한 저서생태계 건강도지수(BHI)를 개발하였고, 본 연구에서는 저서생태계 건강도지수의 개발 과정과 계산방법을 소개하고자 한다. 저서생태계 건강도지수는 국내 연안역과 양식장에서 출현한 225종의 다모류를 대상으로 퇴적물 내 총유기탄소량의 농도 구배와 종별 분포특성을 연관지어 4개의 그룹을 나누고, 각 그룹에 가중치를 부여하는 방식으로 계산된다. 저서생 태계 건강도지수를 이용하여 저서동물군집을 4개의 생태등급(Grade 1: Nomal, Grade 2: Slightly polluted, Grade 3: Moderately polluted, Grade 4: Heavily polluted)으로 나누었다. 개발된 지수를 현장에 적용한 결과, 기존의 평가방법인 다양도 지수나 국외에서 개발된 AMBI와 비교해 보 다 정확하고 계절의 영향을 적게 받아 우리나라 환경을 평가하기에 효과적인 것으로 판단된다. 또한 저서생태계 건강도지수를 사용하면 어장환경을 정량화된 수치에 따라 등급화 할 수 있어 양식장 환경관리에 효율적으로 활용할 수 있을 것이다.
        4,800원
        76.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        The conservation of wetland ecosystems has a significant role in climate change. Notably, the Han River Protected Area, including the Siam-ri wetland and Janghang wetland, provides high biodiversity value. Thus, it is necessary to comprehensively evaluate the function and value of wetland ecosystems. This study evaluated the ecosystem services of Siam-ri and Janghang Wetlands located in the Han River Protected Area using the Rapid Assessment Wetland Ecosystem Services approach, a function-oriented ecosystem analysis. The results were calculated using the Ecosystem Services Index formula to analyze wetland ecosystem services. We also assessed the key ecosystem services based on a focus group interview. We identified that the supporting and cultural services index scores were relatively high in the study area. The results can provide helpful information for sustainable wetland conservation, conservation planning as primary data, and raising awareness for the Han River Protected Area.
        4,600원
        77.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        River estuaries are dynamic and productive ecosystems with high regional biodiversity. Environmental DNA (eDNA) has become a useful approach to assessing biodiversity in aquatic ecosystems. This study was conducted to investigate fish community characteristics and species diversity in two river estuary ecosystems, the Taehwa River and Changwon Stream. We further compared conventional and eDNA metabarcoding analyses of the fish communities. The conventional survey was performed in May, July, and October 2022, while the eDNA analysis was conducted only in May. We observed various fish species with different life histories, including carp, goby, and marine fish. We also found that migratory fish, such as dace Tribolodon hakonensis, sweetfish Plecoglossus altivelis, and eel Auguilla japonica, occurred in the Taehwa River, suggesting high river connectivity. Marine fish species were predominant in the Changwon Stream, as this river is located close to the sea. The diversity indices showed that the Taehwa River generally had higher species richness, evenness, and diversity values than the Changwon Stream. A total of 9-19 species were detected in the conventional survey for the three sites, whereas 11-18 species were found from eDNA analysis. The findings indicate that the sensitivity of eDNA was similar to or higher than that of the conventional method. Our study findings suggest the efficiency and efficacy of eDNA-based fish community monitoring, although with some shortcomings in applying the genetic marker to Korean fish, including no clear-cut distinction for Korean endemic species and/or genetically closely related species groups.
        5,500원
        78.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This study was performed to investigate antioxidant and anti-inflammatory activities of perilla(Perilla frutescens L.) seed, flower and leaf according to extraction condition. Perilla seed extracts(PSE), perilla flower extracts(PFE), perilla leaf extracts(PLE) was extracted by stirring extraction (STE, 25°C), shaking extraction (SHE, 80°C), and sonication assisted extraction(SAE, , 25°C) with 94% ethanol, 60% ethanol and distilled water, followed by analysis of total polyphenol and flavonoid and testing radical scavenging activities. The highest total polyphenol content (5.47, 9.36, 38.58 mg gallic acid equivalent/g), total flavonoid content(5.77, 8.62, 46.44 mg catechin equivalent/g), ABTS(10.68, 19.46, 63.56 mg trolox equivalent/g) and DPPH(6.51, 7.69, 79.73 mg trolox equivalent/g) radical scavenging activity of PSE, PFE and PLE was observed in the HWE with 60% ethanol,. Among the three extraction method, SHE provided the best results for yield, polyphenol, flavonoid content of perilla seed, flower, leaf in comparison to STE or SAE. SHE with 60% ethanol of perilla seed, flower, leaf more effectively inhibited secretion of nitric oxide(NO) and pro-inflammatory cytokine in RAW 264.7 macrophage exposed to LPS compared to other extraction solvent and method. Therefore, these extracts obtained from perilla seed, flower, leaf could be used antioxidant and anti-inflammatory ingredients in the food industry.
        4,000원
        79.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Reported positive ion fragmentation of phenolic acid derivatives in rice (Oryza sativa L.) were summarized based on the literature. A total of eight phenolic acids (4 derivatives of ferulic acid, 3 derivatives of sinapic acid and p-coumaric acid) were isolated and identified from rice (raw and steamed) using UPLC-DAD-QToF/MS. Results revealed that 6-O-feruloylsurose was the major component with 3'-O-sinapoylsucorse being tentatively identified in Oryza sativa L. for the first time as a new hydroxycinnamoyl derivative in rice grains. In our study, raw brown rice had the highest phenolic acid contents with Samkwang showing higher phenolic acid content than Saeilmi and Sindongjin (12.41 vs. 7.89 and 3.10 mg/100 g dry weight, respectively). Of all varieties, brown rice had higher phenolic acid contents than white rice. These contents decreased considerably when rice was steamed whereas, p-coumaric acid and ferulic acid contents were increased. Additionally, contents of rice (raw and steamed) can be used as a fundamental report for new rice varieties.
        4,000원
        80.
        2023.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.
        4,000원
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